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An insight into the role of autophagy in cell responses in the aging and neurodegenerative brain

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dc.contributor.authorCaballero, B
dc.contributor.authorCoto-Montes, A.
dc.date.accessioned2017-03-08T15:26:30Z
dc.date.available2017-03-08T15:26:30Z
dc.date.issued2012
dc.description.abstractOxidative stress, inflammation and the aggregation of oxidized, misfolded or aberrant proteins in the brain induces deregulations in programmed cell death: apoptosis and autophagy. Apoptosis is one of processes implicated in aging and neurodegenerative pathologies, and for the last decade, has been one of the most studied processes due to its essential role, not only in aging, but also in many neurodegenerative diseases, including Parkinson’s, Alzheimer’s and Huntington’s. However, autophagy being the major intracellular pathway for the degradation and recycling of long-live proteins and organelles is widely involved in the pathogenesis or prevention of many age-related diseases, including neurodegenerative conditions. Recently, autophagy activation has been considered as part of the cellular responses to elevated oxidative stress, eliminating unwanted, damaged and oxidative structures; thus favouring, in this way, the key anti-aging mechanism associated with the caloric restriction. Longevity factors, such as sirtuins, and redox-sensitive transcriptional factors, such as NF-κB and p53, can also regulate basal autophagy in cells, with a direct impact on longevity and the development of inflammation and neurodegeneration. Here, we reviewed the critical changes of autophagy in the aging and neuro-degenerative brain and the role of key regulators of autophagy, which are directly related to oxidative stress, inflammation and longevity pathways.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Hispathology, vol. 27, n. 3, 2012
dc.identifier.issn2013-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/52374
dc.languageenges
dc.publisherF. Hernandez y JuanF. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología.es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeurodegenerationes
dc.subjectAutophagyes
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biologíaes
dc.titleAn insight into the role of autophagy in cell responses in the aging and neurodegenerative braines
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.27, nº 3 (2012)