Publication: Effect of low or high dietary calcium on the morphology of the rat femur
Authors
chen, H. ; Hayakawa, D. ; Emura, S. ; Ozawa, Y. ; Okumura, T. ; Shoumura, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The present study compared the effect of a
calcium deficit or surfeit on femurs. Young female rats
were fed with the normal (1.18%), low (0.05%), or high
(2.00%) calcium diet for 3, 7, 15 or 30 days. Two groups
received the low calcium diet for the first 15 days and
then were followed by the normal (L-N) or high calcium
diets (L-H) for the sequential 15 days. The morphology
of the femur was studied together with serum calcium,
parathyroid hormone (PTH), calcitonin and bone mineral
density (BMD). We did not find any significant changes
in the serum PTH level and bone morphology in the high
calcium group. In the low calcium group, the serum PTH
level increased, BMD of the whole body, the femoral
weight and the femoral trabecular bone decreased as
compared with the normal calcium group. There was a
greater proportion of resorbing surface, less resting
surface and larger vascular canal openings in the femoral
endosteal surfaces in the low calcium group. In the L-N
or L-H group, the femoral trabecular bone increased and
the femoral resorbing surface decreased as compared
with those of the low calcium group. These findings
suggest that high calcium intakes do not affect the bone
mass, and low calcium intakes have a deleterious effect
on bone status, which may be related to vascular
alternations of the bone. Reversing the low income
calcium intake by a higher calcium diet can partially
improve the bone alternations induced by low calcium
intake.
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