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Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.

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dc.contributor.authorNavarro Zaragoza, Javier
dc.contributor.authorMartínez Laorden, Elena
dc.contributor.authorTeruel Fernández, Francisco Javier
dc.contributor.authorGómez Murcia, Victoria
dc.contributor.authorCánovas Cabanes, Alberto
dc.contributor.authorMilanés Maquilón, María Victoria
dc.contributor.authorLaorden Carrasco, María Luisa
dc.contributor.authorAlmela Rojo, Pilar
dc.contributor.departmentFarmacología
dc.date.accessioned2026-04-13T07:27:40Z
dc.date.available2026-04-13T07:27:40Z
dc.date.copyright© 2021 Elsevier Inc
dc.date.issued2021-01-02
dc.description.abstractIntense associative memories develop between drug-paired contextual cues and the drug withdrawal associated aversive feeling. They have been suggested to contribute to the high rate of relapse. Our study was aimed to elucidate the involvement of hypothalamic-pituitary-adrenocortical (HPA) axis activity in the expression and extinction of aversive memory in Swiss and C57BL/6J (B6) mice. The animals were rendered dependent on morphine by i.p. injection of increasing doses of morphine (10–60 mg/kg). The negative state associated with naloxone (1 mg/kg s.c.) precipitated morphine withdrawal was examined by using conditioned place aversion (CPA) paradigm. B6 mice obtained a higher aversion score and took longer to extinguish the aversive memory than Swiss mice. In addition, corticosterone levels were increased after CPA expression. Moreover, corticosterone levels were decreased during CPA extinction in Swiss mice without changes in B6 mice. Pre-treatment with the selective CRF1 receptor antagonist CP-154,526 before naloxone, impaired morphine-withdrawal aversive memory acquisition and decreased the extinction period. CP-154,526 also antagonized the increased levels of corticosterone observed after CPA expression in Swiss mice, without any changes in B6 mice. These results indicate that HPA axis could be a critical factor governing opioid withdrawal memory storage and retrieval, but in a strain or stock-specific manner. The differences observed between Swiss and B6 mice suggest that the treatment of addictive disorders should consider different individual predisposition to associate the aversive learning with the context.
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dc.identifier.citationNavarro-Zaragoza J, Martínez-Laorden E, Teruel-Fernández FJ, Gómez-Murcia V, Cánovas A, Milanés MV, Laorden ML, Almela P. Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis. Pharmacol Biochem Behav. 2021 Feb;201:173106. doi: 10.1016/j.pbb.2021.173106.
dc.identifier.doi10.1016/j.pbb.2021.173106
dc.identifier.eissn1873-5177
dc.identifier.urihttp://hdl.handle.net/10201/225141
dc.languageeng
dc.publisherElsevier
dc.relationMinisterio de Ciencia e Innovación (SAF/FEDER 2017-85679-R), Fundación Séneca (20847/PI/18), Murcia, Spain; y Red de Trastornos Adictivos (RTA; RD12/0028/0003; Instituto de Salud Carlos III)
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0091305721000046
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCPA expression
dc.subjectCPA extinction
dc.subjectMorphine withdrawal
dc.subjectHPA axis
dc.subjectAversive memory
dc.subject.odsObjetivo 3: Salud
dc.titleNaloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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