Publication:
The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?

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Chen-37-621-636-2022.pdf(3.85 MB)
Date
2022
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Authors
Chen, Kuang Qi ; Wei, Bang Hong ; Hao, Shuang Li ; Yang, Wan Xi
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Publisher
Universidad de Murcia, Departamento de Biologia Celular e Histiologia
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DOI
https://doi.org/10.14670/HH-18-457
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info:eu-repo/semantics/article
Description
Abstract
The PI3K/AKT signaling pathway is one of the most crucial regulatory mechanisms in animal cells, which can mainly regulate proliferation, survival and anti-apoptosis in cell lines. In the seminiferous epithelium, most studies were concentrated on the role of PI3K/AKT signaling in immature Sertoli cells (SCs) and spermatogonia stem cells (SSCs). PI3K/AKT signaling can facilitate the proliferation and antiapoptosis of immature Sertoli cells and spermatogenic cells. Besides, in mature Sertoli cells, this pathway can disintegrate the structure of the blood-testis barrier (BTB) via regulatory protein synthesis and the cytoskeleton of Sertoli cells. All of these effects can directly and indirectly maintain and promote spermatogenesis in male testis.
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PI3K/AKT signaling , Sertoli cell , Spermatogonia stem cell , Blood testis barrier , Spermatogenesis
Citation
Histology and Histopathology Vol. 37, nº7 (2022)
URI
http://hdl.handle.net/10201/128692
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Histology and histopathology Vol.37, nº7 (2022)
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