Publication: Sequential expression of glutathione-S-transferase
Authors
Wollina, Uwe ; Paus, R. ; Feldrappe, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The hair follicle is a stnicture showing a very
unique cycling of its epithelial components. It is
innervated by an abundance of peptidergic nerves, and
neuroendocrine cells occur within the epithelium or in
close proximity to it. Recently, it has been suggested that
hair growth may be regulated by neuropeptides. We
therefore investigated the relationship of VIP receptor
expression to intracellular phosphotyrosinase and
caldesmon involved in the control of growth and
differentiation and metabolizing isoenzymes of the
glutathione-S-transferase (GST) family alpha, mu, and pi
during induced anagen of C57 BI-6 mice by immunohistotochemistry.
It was demonstrated that GST isoenzymes
were expressed sequentially in the bulge area
and the inner hair root sheath as well as in the sebaceous
gland epithelium. Caldesmon was present during the
early anagen phases within the bulge region, as was
phosphotyrosinase. However, phosphotyrosinase
expression decreased in late anagen, and recovered again
in post-epilation telogen. VIP receptor was expressed
within the bulge area during anagen V, but was absent
during the other cycle phases. These results suggest a
relationship of protein expression to hair cycle phases
and in particular a physiological function of VIPIVIP
receptor in terminating the extensive hair follicle growth
during anagen 1 to IV.
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