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Platelet rich plasma: a valid augmentation for cartilage scaffolds? a systematic review

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dc.contributor.authorPerdisa, Francesco
dc.contributor.authorFilardo, Giuseppe
dc.contributor.authorDi Matteo, Berardo
dc.contributor.authorMarcacci, Maurilio
dc.contributor.authorKon, Elizaveta
dc.date.accessioned2019-05-20T10:21:14Z
dc.date.available2019-05-20T10:21:14Z
dc.date.issued2014
dc.description.abstractIt has been shown that modern regenerative scaffold-based procedures for the treatment of articular cartilage defects offer good clinical results, although the properties of native healthy cartilage have not yet been matched by any substitute. Several implants have been tested and clinically used over the years to promote articular surface restoration, some of them producing a hyaline-like reparative tissue. There has been an increase in the number of new biological strategies, alone and in combination with scaffolds, to enhance the clinical outcome in patients with chondral disease. Among these innovative methods, one of the most widely used is Platelet-rich Plasma (PRP), based on the rationale of using the growth factors contained in platelet alpha granules to promote tissue regeneration. The aim of the present manuscript is to review systematically the current evidence in pre-clinical and clinical studies for the use of PRP augmented scaffolds to treat chondral or osteochondral disorders.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.citationHistology and Histopathology, vol. 29, nº 7, (2014)
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/70683
dc.languageenges
dc.publisherF. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histologíaes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectPlatelet-rich plasmaes
dc.subjectCartilagees
dc.subjectRegenerative medicinees
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titlePlatelet rich plasma: a valid augmentation for cartilage scaffolds? a systematic reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.29, nº 7 (2014)