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Apoptosis in the developing mouse embryos from T-2 toxin-inoculated dams

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dc.contributor.authorIshigami, M.es
dc.contributor.authorShinozuka, J.es
dc.contributor.authorKatayama, K.
dc.contributor.authorUetsuka, K.
dc.contributor.authorNakayama, Hiroyuki
dc.contributor.authorDoi, K.
dc.date.accessioned2011-02-22T11:09:25Z
dc.date.available2011-02-22T11:09:25Z
dc.date.issued1999
dc.description.abstractT-2 toxin (3mglkg b.w.) was orally inoculated to pregnant mice at 11 days of gestation to examine the effect of T-2 toxin on the developing embryos. At 24 hours after T-2 toxin-inoculation, moderate pyknosis or karyorrhexis was generally observed in some layers of the central nervous system, caudal sclerotomic segment, caudal region of the tongue to pharyngeal- to laryngeal-mesenchyma, trachea and facial mesenchyma. These pyknotic or karyorrhectic nuclei were strongly stained by the modified TUNEL method widely used for the in situ detection of apoptotic nuclei and also showed ultrastructural changes characteristic for apoptosis. This is the first report of mycotoxin-induced apoptosis in embryoses
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19210
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectApoptosises
dc.subjectMouse embryoes
dc.subject.otherCDU::6 - Ciencias aplicadas::63 - Agricultura. Silvicultura. Zootecnia. Caza. Pesca::636 - Veterinaria. Explotación y cría de animales. Cría del ganado y de animales domésticoses
dc.titleApoptosis in the developing mouse embryos from T-2 toxin-inoculated damses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.14, nº 3 (1999)