Publication: Cellular and molecular mechanisms of intestinal elongation in mammals: the long and short of it
Authors
Cervantes, Sara
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia. Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The gastrointestinal tract carries out essential
functions for the organism, including the digestion and
absorption of nutrients. The cells lining the lumen of the
gut tube derive from the endoderm, one of the three
germ layers formed during gastrulation. The length of
the intestinal tract determines its digestive and
absorptive capacity, and so the intestine expands several
times the length of the whole body to ensure an adequate
absorptive area to meet nutritional demands. However,
the endoderm starts out as a small sheet of cells spanning
less than the whole length of the head-fold embryo. In
order to achieve its final shape and size, the cells in the
endoderm undergo extensive growth and profound
morphogenetic changes, which are governed by
embryonic signaling pathways and transcription factors.
This review, based on mouse development, summarizes
our current knowledge of the cellular and molecular
mechanisms underlying the morphogenetic changes that
participate in shaping the mature intestinal tract in
vertebrates.
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Citation
Histology and histopathology, Vol. 28, n.º 4 (2013)
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