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Morphological changes in microglia in the mouse brain during postnatal development and obesity

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dc.contributor.authorChu Zhang
dc.contributor.authorGe Gao
dc.contributor.authorXiaonan Shao
dc.contributor.authorYJing Kang
dc.contributor.authorXin Yan
dc.contributor.authorJuntang Lin
dc.contributor.authorLiang Qiao
dc.contributor.authorYang Li1
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2026-02-17T09:55:16Z
dc.date.available2026-02-17T09:55:16Z
dc.date.issued2026
dc.description.abstractMicroglia are innate immune cells in the central nervous system (CNS) and play critical roles in proper brain development and function. During postnatal development, microglia have a highly plastic morphology and change rapidly in response to the temporal brain environment. However, their dynamics and phenotypes during this period are still not fully elucidated. Here, we systematically elucidated microglial density and morphological changes during postnatal development as well as in pathological obese conditions. Our results demonstrated a spatiotemporal distribution of microglia in different brain regions associated with gradually increased microglial complexity during postnatal development. Moreover, microglia become reactive in most brain regions of obese mice, but their morphological diversity has a region-specific manner, with an obvious alteration in the hypothalamus. Overall, our data emphasized the morphological dynamics of microglia following developing time windows and provided the basic information for future investigations.
dc.formatapplication/pdf
dc.format.extent14
dc.identifier.doihttps://doi.org/10.14670/HH-18-976
dc.identifier.eissn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/206421
dc.languageeng
dc.relationSin financiación externa a la Universidad
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectMorphology
dc.subjectDevelopment
dc.subjectObesity
dc.subjectMicroglia
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleMorphological changes in microglia in the mouse brain during postnatal development and obesity
dc.typeinfo:eu-repo/semantics/article
dspace.entity.typePublication
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Histology and histopathology, Vol.41, Nº3, (2026)