Publication: Review of collecting duct carcinoma with focus on clinical and pathobiological aspects
Authors
Kuroda, Naoto ; Toi, M. ; Hiroi, Makoto ; Enzan, H.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
In recent years, the concept of collecting duct
carcinoma (CDC) has been established. CDCs constitute
about 0.4 to 2% of RCCs. Macroscopically, CDCs occur
in the renal medulla. On the cut surface, they are
generally firm, white or grey and poorly circumscribed.
Histologically, CDCs are characterized by various
cytological and histological appearances. Furthermore,
desmoplastic stromal reaction around the tumor and
atypical hyperplastic changes or carcinoma in situ in the
adjacent medullary collecting duct are freqently
observed. Histological distinction from papillary RCCs
is most important, because both tumors share some
structural and histochemical features, and it seems that
some investigators have confused diagnostic criteria for
CDCs. On the other hand, the concept of medullary
carcinoma, which preferentially occurs in a black race
and shows histological features similar to those of CDC,
has also recently been established. Although there have
been few studies on chromosomal abnormalities of
CDCs and consistent abnormalities have not been
identified, a recent study using microsatellite analysis
has shown a high frequency (60%) of LOH in 1q32.1-
32.2. Further studies are needed to elucidate the genetic
characteristics of CDCs and to determine the
relationship or difference between CDCs and medullary
carcinomas.
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