Publication: The skin injury induced by high energy dose of ultraviolet in hairless descendants of Mexican hairless dogs
Loading...
Date
1997
Authors
Ishii, Y. ; Kimura, T. ; Itagaki, S. ; Doi, K.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Histopathological changes in the dorsal skin
of hairless descendants of Mexican hairless dogs
(MHDs) exposed to artificial irradiation with high
energy dose ( 1 8 0 k ~ l m ~of) ultraviolet (UV) rays
(UVA+B) were investigated.
Macroscopically, erythema and edema were
observed in the irradiated skin at 1 day after irradiation
(DAI), and blister formation occurred except one dog at
2 DAI. Erythema almost disappeared at 5 DAI, and at 6
DAI, the skin recovered to almost normal state. Light
microscopically, sunburn cells were observed at 1 DAI.
Then intercellular edema and blister formation in the
epidermis and dermal edema were evident at 2 and 3
DAI. At 6 DAI, the skin showed almost normal features
except for slight epidermal thickening, but melanin
granules, which were distributed in almost the whole
length of the epidermis before UV irradiation, were
detected only in cells which seemed to be melanocytes
except one dog. Dihydroxyphenylalanine (D0PA)-
positive melanocytes almost disappeared at 1 and 2 DAI,
and at 6 DAI, the number of DOPA-positive
melanocytes increased over the leve1 before UV
irradiation. The ultrastructural features of melanocytes
were characterized by vacuolated cytoplasm, decreased
melanosomes, irregular-shaped nuclei and shortened
dendrites at 1 DAI, and returned to normal at 6 DAI.
These findings of melanocytes reflect the severity of the
skin injury and support weak suntan reaction in this case.
In conclusion, severe form of UV-induced skin injury
seen in humans could be reproduced in hairless
descendants of MHDs exposed to high energy dose of
artificial UVA+B.
publication.page.subject
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.