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Does diabetic state affect CO-localization of peptide W and enteroglucagon in colonic endocrine cells?

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dc.contributor.authorSpangeus, A.es
dc.contributor.authorForsgren, Sture
dc.contributor.authorEl-Salhy, M.
dc.date.accessioned2011-02-22T11:19:49Z
dc.date.available2011-02-22T11:19:49Z
dc.date.issued2000
dc.description.abstractBackground: Changes in the numbers of PYY- and enteroglucagon-immunoreactive cells in colon of animal models of human diabetes have been reported. As these peptides CO-localize in the same cells it is possible that the observed changes are a result of changes in CO-localization. Methods: Animal models of human type 1 and type 2 diabetes, namely the non-obese diabetic (NOD) mouse and the obese (oblob) mouse, were studied. As controls for the NOD mice, BALBIcJ mice were used and for oblob mice, homozygous lean (+l+) mice were used. Tissue samples from colon were double-immunostained for PYY and enteroglucagon according to the indirect immunofluorescence method. Results: CO-localization of enteroglucagon and PYY was found in colonic endocrine cells in all groups investigated. Compared with controls, pre-diabetic NOD mice showed a decreased proportion of enteroglucagon1PYY CO-localization. There was no difference in diabetic NOD mice or diabetic oblob mice when compared with controls. Conclusions: Whereas the number of cells containing solely enteroglucagon and solely PYY increases in pre-diabetic NOD mice, production of enteroglucagon in PYY-immunoreactive cells decreases. Although the numbers of PYY and enteroglucagon cells have been reported to be changed in both diabetic NOD mice and in obese mice, the balance between CO-expressing and mono-expressing cells seems to be preserved.es
dc.formatapplication/pdfes
dc.format.extent5es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/19265
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectDiabeteses
dc.subjectColones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleDoes diabetic state affect CO-localization of peptide W and enteroglucagon in colonic endocrine cells?es
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.15, nº 1 (2000)