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Gastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumors

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dc.contributor.authorTakenaka, Y.es
dc.contributor.authorTsukamoto, T.es
dc.contributor.authorMizoshita, T.
dc.contributor.authorOgasawara, N.
dc.contributor.authorHirano, N.
dc.contributor.authorOtsuka, T.
dc.contributor.authorBan, H.
dc.contributor.authorNakamura, T.
dc.contributor.authorYamamura, Y.
dc.contributor.authorKaminishi, M.
dc.contributor.authorTatematsu, M.
dc.date.accessioned2012-05-21T12:09:01Z
dc.date.available2012-05-21T12:09:01Z
dc.date.issued2007
dc.description.abstractWe have previously suggested that an origin of a stomach cancer is from a progenitor cell specializing toward exocrine cell (Exo-cell) lineages. To clarify whether our hypothesis is correct or not, we analyzed the expression of Exo-cell and endocrine cell (End-cell) markers in a series of lesions for comparison. We evaluated chromogranin A (CgA) expression in 37 early and 73 advanced stomach cancers, in 30 stomach adenomas, in 8 carcinoid tumors, and in 4 endocrine cell carcinomas (ECCs) with assessment of gastric and/or intestinal (G/I) phenotypes in both Exo-cell and End-cell by immunohistochemistry. CgA expression was observed in 10.8% of the early and 16.4% of the advanced stomach cancers, respectively. The End-cell G/I phenotypes were in line with the Exo-cell counterparts in the CgA-positive stomach cancerous areas, and there was strong association between Cdx2 expression and the intestinal End-cell markers. All of the adenoma cases had the intestinal Exo-cell phenotypic expression, with the positive link between Exo-cell and End-cell G/I phenotypes. All stomach carcinoids had CgA expression but no expression of Exo-cell markers. In conclusion, most stomach cancers might develop from a progenitor cell specializing towards Exo-cell lineages, but some cases possessed both Exo-cell and End-cell markers with maturely differentiated phenotypes. In such cases, Exo-cell and End-cell phenotypes were found to correlate strongly, suggesting the possibility of histogenesis from “cancer stem cells”.es
dc.formatapplication/pdfes
dc.format.extent13es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/27557
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectStomach cancerses
dc.subjectEndocrine cellses
dc.subject.other616.3 - Patología del aparato digestivo. Odontologíaes
dc.titleGastric and intestinal phenotypic correlation between exocrine and endocrine components in human stomach tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.22, nº 3 (2007)