The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model

Baenas, Nieves; Vega-García, Angélica; Manjarrez-Marmolejo, Joaquín; Moreno, Diego A.; Feria-Romero, Iris A.

Publication:
The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model

dc.contributor.author	Baenas, Nieves
dc.contributor.author	Vega-García, Angélica
dc.contributor.author	Manjarrez-Marmolejo, Joaquín
dc.contributor.author	Moreno, Diego A.
dc.contributor.author	Feria-Romero, Iris A.
dc.date.accessioned	2025-01-28T20:16:10Z
dc.date.available	2025-01-28T20:16:10Z
dc.date.issued	2023-10-13
dc.description	© 2023 The Authors. This document is the published version of a published work that appeared in final form in Biomedicine & Pharmacotherapy This document is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0 To access the final edited and published work see: https://doi.org/10.1016/j.biopha.2023.115720
dc.description.abstract	The aggressive and incurable diffuse gliomas constitute 80% of malignant brain tumors, and patients succumb to recurrent surgeries and drug resistance. Epidemiological research indicates that substantial consumption of fruits and vegetables diminishes the risk of developing this tumor type. Broccoli consumption has shown beneficial effects in both cancer and neurodegenerative diseases. These effects are partially attributed to the isothiocyanate sulforaphane (SFN), which can regulate the Keap1/Nrf2/ARE signaling pathway, stimulate detoxifying enzymes, and activate cellular antioxidant defense processes. This study employs a C6 rat glioma model to assess the chemoprotective potential of aqueous extracts from broccoli seeds, sprouts, and inflorescences, all rich in SFN, and pure SFN as positive control. The findings reveal that administering a dose of 100 mg/kg of broccoli sprout aqueous extract and 0.1 mg/kg of SFN to animals for 30 days before introducing 1 × 104 cells effectively halts tumor growth and progression. This study underscores the significance of exploring foods abundant in bioactive compounds, such as derivatives of broccoli, for potential preventive integration into daily diets. Using broccoli sprouts as a natural defense against cancer development might seem idealistic, yet this investigation establishes that administering this extract proves to be a valuable approach in designing strategies for glioma prevention. Although the findings stem from a rat glioma model, they offer promising insights for subsequent preclinical and clinical research endeavors.
dc.format	application/pdf	es
dc.format.extent	27	es
dc.identifier.citation	Biomedicine & Pharmacotherapy Vol. 168, December 2023, 115720
dc.identifier.doi	https://doi.org/10.1016/j.biopha.2023.115720
dc.identifier.issn	Print.:0753-3322
dc.identifier.issn	Electronic.: 1950-6007
dc.identifier.uri	http://hdl.handle.net/10201/149540
dc.language	eng	es
dc.publisher	Elsevier	es
dc.relation	Health Research Coordination-IMSS, FIS/IMSS/PROT/G17-2/1725, Mexico.	es
dc.relation.publisherversion	https://www.sciencedirect.com/science/article/pii/S0753332223015184	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Broccoli aqueous extracts	es
dc.subject	Sprouts
dc.subject	Sulforaphane
dc.subject	Brain tumor
dc.subject	C6 rat glioma model
dc.title	The preventive effects of broccoli bioactives against cancer: Evidence from a validated rat glioma model	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es