Publication: Proliferative activity of well differentiated
neuroendocrine tumours of the gut
Authors
Zimmermann, M.E. ; Bosman, F.T.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Neuroendocrine tumours of the
gastrointestinal tract are relatively uncommon neoplasms
with, in spite of their characteristic morphology,
relatively unpredictable biological behaviour. In some
sites, notably the appendix, these tumours are largely
benign whereas at other localisations, such as the small
bowel, metastases occur and the outcome is less
favourable. Given the lack of discriminative power of
histological parameters, immunohistochemical
parameters have been proposed. Of these the Ki-67
index, as an indicator of proliferative activity, has shown
some promise.
In order to assess their proliferative activity and the
potential contribution of this parameter to defining
biological behaviour, we performed Ki-67
immunostaining of a series of 64 well differentiated
neuroendocrine tumours of the gut (stomach, small
bowel, appendix, colon and rectum). Ki-67 labeling
index, based upon counting of up to 5000 cells, ranged
between 0 and 6.1‰. No difference was found according
to age, gender, size, location or TNM classification. Ki-
67 labeling index of midgut endocrine tumours of long
term surviving patients did not differ from patients that
died.
We conclude that Ki-67 labeling index as an
indicator of proliferative activity of well differentiated
neuroendocrine tumours of the digestive tract does not
correlate with size nor site nor stage. Even though only
small numbers of tumours could be analysed, which
hampered appropriate statistical analysis, it seems
unlikely that proliferative activity has potential as an
independent prognostic parameter for this type of
tumour.
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