Publication: The effects of low laser irradiation on angiogenesis in injured rat tibiae
Authors
Garavello, I. ; Baranauskas, V. ; da Cruz Hoflingl, M.A.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The influence of He-Ne laser radiation on the
formation of new blood vessels in the bone marrow
compartment of a regenerating area of the mid-cortical
diaphysis of the tibiae of young adult rats was studied. A
small hole was surgically made with a dentistry burr in
the tibia and the injured area received a daily laser
therapy over 7 or 14 days transcutaneously starting 24 h
from surgery. Incident energy density dosages of 31.5
and 94.5 Jcm-2 were applied during the period of the
tibia wound healing investigated. Light microscopic
examination of histological sections of the injured area
and quantification of the newly-formed blood vessels
were undertaken. Low-level energy treatment
accelerated the deposition of bone matrix and
histological characteristics compatible with an active
recovery of the injured tissue. He-Ne laser therapy
significantly increased the number of blood vessels after
7 days irradiation at an energy density of 94.5 Jcm-2, but
significantly decreased the number of vessels in the 14-
day irradiated tibiae, independent of the dosage. These
effects were attributed to laser treatment, since no
significant increase in blood vessel number was detected
between 8 and 15 non-irradiated control tibiae.
Molecular mechanisms involved in low-level laser
therapy of angiogenesis in post-traumatic bone
regeneration needs further investigation.
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