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Immunohistochemical analysis of ß3 integrin (CD61): expression in pig tissues and human tumors

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dc.contributor.authorMoreno, A.es
dc.contributor.authorLucena, C.es
dc.contributor.authorLopez, A.
dc.contributor.authorGarrido, J.J.
dc.contributor.authorPérez de la Lastra, J.M.
dc.contributor.authorLlanes, D.
dc.date.accessioned2011-05-11T10:58:01Z
dc.date.available2011-05-11T10:58:01Z
dc.date.issued2002
dc.description.abstractCD61 is a membrane glycoprotein that associates with CD41 (aIIb) to form the heterodimeric complex gpIIb/IIIa (CD41/CD61), predominantly expressed in platelets and megakariocytes. CD61 or ß3 integrin also associates with av (CD51) to form the vitronectin receptor, which is expressed in many tissues. We have used a monoclonal antibody against the porcine gpIIIa or CD61 (JM2E5) to study the distribution of this molecule in different normal pig tissues. As in humans, CD61 was broadly expressed in all tissues examined. In the kidney, strong expression of CD61 was observed in epithelial cells from renal tubules. In the testis, CD61 expression was detected in the Leydig cells. However, in liver, CD61 was weak or not detected. Many integrins are particularly involved in tumogenicity and in tumor progression mediating cellcell interaction. Immunofluorescence experiments using cultured human tumor HeLa cells showed nuclear and cytoplasmic staining of mAb JM2E5. Immunohistochemical analysis of human tumor sections from several organs showed a heterogeneus distribution in metastatic cases from colon and breast carcinoma. However, no staining was found in metastasis from melanoma.es
dc.formatapplication/pdfes
dc.format.extent6es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/20776
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectß3 integrines
dc.subjectHuman tumorses
dc.subject.otherCDU::5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citologíaes
dc.titleImmunohistochemical analysis of ß3 integrin (CD61): expression in pig tissues and human tumorses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.17, nº 2 (2002)