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Ezrin and moesin expression in canine and feline osteosarcoma

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dc.contributor.authorHlavaty, Juraj
dc.contributor.authorWolfesberger, Birgitt
dc.contributor.authorHauck, Marlene
dc.contributor.authorObermayer Pietsch, Barbara
dc.contributor.authorFuchs Baumgartinger, Andrea
dc.contributor.authorMiller, Ingrid
dc.contributor.authorWalter, Ingrid
dc.date.accessioned2022-02-28T11:43:04Z
dc.date.available2022-02-28T11:43:04Z
dc.date.issued2017
dc.description.abstractBiological features of canine osteosarcomas (OS) differ markedly from those found in feline and resemble more human osteosarcomas, in particular for their high rate of metastasis and poor prognosis. Ezrin, radixin and moesin are members of the ERM protein family and link the actin cytoskeleton with the cell membrane. Ezrin and moesin have been shown to be of prognostic significance in tumor progression due to their role in the metastatic process. The objective of this study was to analyze ezrin and moesin protein expression in a series of dog (n=16) and cat (n=8) osteosarcoma samples using immunohistochemistry and western blot techniques. We found that cat OS have a higher moesin expression compared to dog OS, however, the active phosphorylated forms of moesin and ezrin Tyr353 were more abundant in the dog samples. A statistically significant difference was found for the low and high immunohistochemical scores of ezrin and pan-phosphoERM proteins between cat and dog. Although phosphoezrin Thr567 was higher in feline OS, the membranous localization in dog OS samples indicates the presence of the biologically active form. Therefore, the observed differences in phosphorylated forms of ezrin and moesin status should be further studied to demonstrate if they are relevant for different biological behavior between dog and cat OS.es
dc.formatapplication/pdfes
dc.format.extent12es
dc.identifier.citationHistology and Histopathology, Vol.32, nÂş8, (2017)
dc.identifier.doiDOI: 10.14670/HH-11-848
dc.identifier.issn1699-5848
dc.identifier.issn0213-3911
dc.identifier.urihttp://hdl.handle.net/10201/117467
dc.languageenges
dc.publisherUniversidad de Murcia. Departamento de BiologĂ­a Celular e HistologĂ­aes
dc.relationSin financiaciĂłn externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectCates
dc.subjectDoges
dc.subjectOsteosarcomaes
dc.subjectEzrines
dc.subjectMoesines
dc.subjectWestern blotes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - PatologĂ­a. Medicina clĂ­nica. OncologĂ­aes
dc.titleEzrin and moesin expression in canine and feline osteosarcomaes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.32, nÂş8 (2017)