Publication: Human papillomaviruses and DNA ploidy in anal condylomata acuminata
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Date
2000
Authors
Rihet, S. ; Bellaich, P. ; Lorenzato, M. ; Bouttens, D. ; Bernard, P. ; Birembaut, P. ; Clavel, C.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Previous studies have emphasized the
usefulness of DNA ploidy measurement and Human
Papillomavirus (HPV) detection as pronostic markers in
low grade cervical lesions. We addressed the eventual
relationship between HPV type, DNA profile, and p53
tumor suppressor protein expression in anal condylomata
acuminata to eventually determine parameters which
may be considered as predictive risk factors for the
development of cancer. DNA ploidy was assessed by
image cytometry after Feulgen staining of contiguous
serial sections of 45 anal condylomata acuminata
without atypia containing HPV detected by in situ
hybridization and Polymerase Chain Reaction (PCR).
p53 expression was detected by immunohistochemistry.
DNA aneuploidy was found in 53.3% of these lesions,
48.9% containing non oncogenic HPV types 6 andtor 11
and 4.4% harbouring HPV types 11 and 18. The DNA
diploid lesions were all associated with non oncogenic
HPV types 6 andtor 11 and one case also contained HPV
type 33. There was no significant correlation between
the detection of DNA aneuploidy and the presence of
immunodetected p53. DNA aneuploidy was not related
to the presence of oncogenic HPV in anal condylomata
acuminata. The DNA aneuploid profile frequently
observed, especially in lesions associated with non
oncogenic HPV types, is not yet well explained and
cannot be considered as a prognostic factor. In contrast,
a more intensive clinical follow-up should be proposed
in patients with oncogenic HPV associated to DNA
aneuploidy.
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