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Dietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: a review

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dc.contributor.authorMartínez-Montoro, José Ignacio
dc.contributor.authorMartínez-Sánchez, María Antonia
dc.contributor.authorBalaguer-Román, Andrés
dc.contributor.authorGil-Martínez, José
dc.contributor.authorMesa-López, María José
dc.contributor.authorEgea Valenzuela, Juan
dc.contributor.authorRuiz Alcaraz, Antonio José
dc.contributor.authorQueipo-Ortuño, María Isabel
dc.contributor.authorFerrer Gómez, Mercedes
dc.contributor.authorFernández García, José Carlos
dc.contributor.authorRamos-Molina, Bruno
dc.contributor.departmentBioquímica y Biología Molecular B e Inmunología
dc.contributor.otherFacultad de Biología
dc.date.accessioned2026-01-14T11:19:59Z
dc.date.available2026-01-14T11:19:59Z
dc.date.copyright© 2022 IJS Publishing Group Ltd.
dc.date.issued2022-07-05
dc.description.abstractColorectal cancer (CRC) is the third most frequent malignancy and the second cause of cancer death worldwide. Several factors have been postulated to be involved in CRC pathophysiology, including physical inactivity, unhealthy dietary habits, obesity, and the gut microbiota. Emerging data suggest that the microbiome may play a key role in CRC prognosis and derived complications in patients undergoing colorectal surgery. On the other hand, dietary intervention has been demonstrated to be able to induce significant changes in the gut microbiota and related metabolites in different conditions; therefore, the manipulation of gut microbiota through dietary intervention may constitute a useful approach to improve perioperative dysbiosis and post-surgical outcomes in patients with CRC. In this article, we review the role of the gut microbiota in CRC surgery complications and the potential therapeutic modulation of gut microbiome through nutritional intervention in patients with CRC undergoing surgery.
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dc.format.extent9
dc.identifier.citationInternational Journal of Surgery 104 (2022) 106751
dc.identifier.doihttps://doi.org/10.1016/j.ijsu.2022.106751
dc.identifier.issn1743-9191
dc.identifier.urihttp://hdl.handle.net/10201/186789
dc.languageeng
dc.publisherElsevier
dc.relationThis work was funded by the Institute of Health “Carlos III” (ISCIII), and co-funded by the Fondo Europeo de Desarrollo Regional-FEDER (grant number PI20/00505). J.C.F.G. was supported by an intensification research program (INT21/00078, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER), M.A.M.S was supported by a PFIS doctoral fellowship (FI21/00003, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER), and B.R.M. was supported by the “Miguel Servet Type I′′program (CP19/00098, ISCIII, Spain; co-funded by the Fondo Europeo de Desarrollo Regional-FEDER).
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1743919122005283?via%3Dihub
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectGut microbiota
dc.subjectColorectal surgery
dc.subjectAnastomotic leak
dc.subjectNutritional therapy
dc.subjectColorectal cancer
dc.subject.odsNo relacionado con ningún objetivo de desarrollo sostenible
dc.titleDietary modulation of gut microbiota in patients with colorectal cancer undergoing surgery: a review
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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