Publication: Circulating nucleic acids in plasma
and serum (CNAPS) and its relation to stem
cells and cancer metastasis: state of the issue
Authors
García-Olmo, Dolores C. ; Ruiz-Piqueras, R.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The presence of circulating cell-free nucleic
acids has been demonstrated both in disease and health.
In the last decade, a burst of papers about Circulating
Nucleic Acids in Plasma and Serum (CNAPS) have been
found in the literature, showing the scientific interest
raised by this phenomenon and their putative clinical
interest, especially in the field of cancer. Today, the
detection of extracellular tumor-derived DNA and/or
RNA is considered by many authors as a new molecular
marker for situations such as cancer diagnosis,
monitoring the outcome of a disease and, even, as a
treatment response indicator. Furthermore, in some
studies it has been suggested a possible role of tumor
CNAPS in the development of metastasis. Specifically,
the hypothesis known as the "genometastasis
hypothesis" proposes that stem cells might be naturally
transfected with dominant oncogenes as a result of
dissemination of such genes in the plasma.
On the other hand, current studies concerned with
the biology of metastatic cells are increasingly being
focused on the striking similarities found between these
cells and stem cells.
In this review we intend to expound and integrate
two theories about metastatization: the "genometastasis
hypothesis" and the idea of stem cells as cancer stem
cells.
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