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Effects of fluoride and calcium phosphate-based varnishes in children at high risk of tooth decay: a randomized clinical trial

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dc.contributor.authorPoza-Pascual, Andrea
dc.contributor.authorSerna-Muñoz, Clara
dc.contributor.authorPérez-Silva, Amparo
dc.contributor.authorMartínez Beneyto, Yolanda
dc.contributor.authorCabello, Inmaculada
dc.contributor.authorOrtiz Ruiz, Antonio José
dc.contributor.departmentDermatología, Estomatología, Radiología y Medicina Física
dc.date.accessioned2024-06-19T11:23:47Z
dc.date.available2024-06-19T11:23:47Z
dc.date.issued2021-09-24
dc.description© 2021 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in International Journal of Environmental Research and Public Health. To access the final edited and published work see https://doi.org/10.3390/ijerph181910049
dc.description.abstractThe aim of this study was to investigate the effect of the application of two varnishes—MI Varnish (5% sodium fluoride with CPP-ACP) and Clinpro White Varnish (5% sodium fluoride with fTCP)—applied every three months in children with high caries risk for 12 months on plaque indexes, salivary pH, salivary lactic acid and chemical elements concentrations. Methods: We included 58 children aged 4–12 years, assigned to control (placebo), Clinpro and MI groups. Baseline and three-month saliva samples were taken. We assessed changes in pH, lactic acid concentrations and chemical elements in saliva. Results: At 12 months, all groups showed a nonsignificant increase in pH levels and a reduction in lactic acid, which was greatest in the placebo group. There was a significant reduction in 24Mg (p = <0.001), 31P (p = 0.033) and 66Zn (p = 0.005) levels in the placebo group (p ≤ 0.05), but not in the other elements studied: 23Na, 27Al, 39K, 44Ca, 52Cr, 55Mn, 57Fe, 59Co, 63Cu, 75As, 111Cd, 137Ba, 208Pb and 19F. Conclusions: Neither pH, lactic acid concentrations or most salivary chemical elements were useful in defining patients at high risk of caries or in monitoring the effect of MI Varnish and Clinpro White Varnish after three-month application for 12 months. However, the appearance of new cavities was stopped, and the hygiene index improved, probably due to hygienic and dietary measures and the use of fluoridated toothpaste. Trial registration: ISRCTN registry, ISRCTN13681286.es
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dc.format.extent15es
dc.identifier.citationInt. J. Environ. Res. Public Health 2021, 18(19), 10049
dc.identifier.doihttps://doi.org/10.3390/ijerph181910049
dc.identifier.issnPrint: 1661-7827
dc.identifier.issnElectronic: 1660-4601
dc.identifier.urihttp://hdl.handle.net/10201/142447
dc.languageenges
dc.publisherMDPI
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.mdpi.com/1660-4601/18/19/10049
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSalivaes
dc.subjectRemineralizationes
dc.subjectPhosphate-based varnisheses
dc.subjectCarieses
dc.subjectHigh risk of carieses
dc.subjectVarnishes
dc.subjectFluoridees
dc.subjectPHes
dc.subjectLactic acides
dc.subjectChemical elementses
dc.titleEffects of fluoride and calcium phosphate-based varnishes in children at high risk of tooth decay: a randomized clinical triales
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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