Publication: Concentrations of C-reactive protein in effusions in dogs
Authors
Parra Muñoz, María Dolores ; Papasouliotis, K. ; Cerón Madrigal, José Joaquín
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Publisher
Wiley, British Veterinary Association
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DOI
https://doi.org/10.1136/vr.158.22.753
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info:eu-repo/semantics/article
Description
© 2006. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/. This document is the Accepted version of a Published Work that appeared in final form in Veterinary Record. To access the final edited and published work see https://doi.org/10.1136/vr.158.22.753
Abstract
The concentration of C-reactive protein (CRP) was measured in effusions from 50 dogs to assess the potential
for measuring this protein to differentiate body cavity fluids. The effusions were classified as either
transudates, modified transudates or exudates according to their total protein concentration, total
nucleated cell count, cytological findings and aetiology, and the concentration of CRP was determined by a
time-resolved immunofluorometric assay. There were significant differences between the concentrations of
CRP in the three types of effusion; the highest concentrations were observed in the exudates (4·47 to 54·59
µg/ml), the lowest were in the transudates (0·0094 to 7·87 µg/ml), and the modified transudates contained
intermediate concentrations of CRP (0·045 to 10·78 µg/ml). A cut-off value of 4 µg/ml had a sensitivity of 100
per cent and a specificity of 94·4 per cent for differentiating transudates from exudates, and a cut-off value
of 11 µg/ml had a sensitivity of 88·2 per cent and a specificity of 100 per cent for distinguishing modified
transudates from exudates. However, a cut-off value of 1 µg/ml had a lower sensitivity (80 per cent) and an
unacceptably low specificity (66·7 per cent) for differentiating transudates from modified transudates.
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Citation
Veterinary Record 2006 158: 753-757
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