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Nanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivity

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dc.contributor.authorCollado-González, Mar
dc.contributor.authorPereira, Irina
dc.contributor.authorPereira-Silva, Miguel
dc.contributor.authorFerreira, Laura
dc.contributor.authorCaldas, Mariana
dc.contributor.authorMagalhães, Mariana
dc.contributor.authorFigueiras, Ana
dc.contributor.authorRibeiro, António J.
dc.contributor.authorVeiga, Francisco
dc.contributor.authorSantos, Ana Claudia
dc.contributor.departmentBiología Celular e Histología
dc.date.accessioned2024-02-10T00:15:17Z
dc.date.available2024-02-10T00:15:17Z
dc.date.issued2019-04-15
dc.description©2019. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Colloids and Surfaces B: Biointerfaces. To access the final edited and published work see https://doi.org/10.1016/j.colsurfb.2019.04.030es
dc.description.abstractResveratrol (RES), also known as 3,5,4′-trihydroxystilbene, is a polyphenolic phytoalexin that has been widely researched in the past decade due to its recognized numerous biological activities. Despite the potential benefits of RES, its effective use is limited due to its poor solubility, photosensitivity and rapid metabolism, which strongly undermine RES bioavailability and bioactivity. Thereby, recently, nanotechnology appeared as a po- tential strategy to circumvent RES physicochemical and pharmacokinetics constrains. However, only few studies have addressed the crucial in vivo suitability of the developed delivery systems to improve RES efficacy. Facing this scenario, in the present review, it is intended to present and discuss the in vivo resveratrol bioavailability and bioactivity, following its encapsulation or conjugation in nanotechnology-based carriers, contemplating their pharmacokinetics effectiveness.es
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dc.identifier.citationColloids and Surfaces B: Biointerfaces 180 (2019) 127–140
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2019.04.030
dc.identifier.issn1873-4367
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/10201/139164
dc.languageenges
dc.publisherElsevier Sci Ltdes
dc.relationThis work is funded from Portugal National Funds (FCT/MCTES, Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior) through project UID/QUI/50006/2013, co-financed by European Union (FEDER under the Partnership Agreement PT2020). It was supported as well by the grants FCT PTDC/ CTM-BIO/1518/2014 and FCT PTDC/BTM-MAT/30255/2017 from the Portuguese Foundation for Science and Technology (FCT, Fundação para a Ciência e a Tecnologia) and the European Community Fund (FEDER) through the COMPETE2020 program. The authors wish to acknowledge Fundação para a Ciência e a Tecnologia (FCT), Portuguese Agency for Scientific Research, for financial support through the Research Project POCI-01-0145-FEDER-016642. Irina Pereira ac- knowledges the PhD research grant SFRH/BD/136892/2018 funded by FCT and Programa Operacional Capital Humano (POCH). Laura Ferreira recognizes the PhD grant PD/BDE/142964/2018 attributed by FCT and Laboratórios Basi from Drugs R&D Doctoral Program. Mar Collado-González acknowledges a postdoctoral fellowship (grant no. 20381/PD/17) from Fundación Séneca-Agencia de Ciencia y Tecnología de la Región de Murcia (CARM)es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S092777651930253X?via%3Dihubes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectResveratroles
dc.subjectNanotechnologyes
dc.subjectNanocarrierses
dc.subjectNanoparticleses
dc.subjectNanoencapsulationes
dc.subjectNanoformulationses
dc.subjectBioavailabilityes
dc.subjectBioactivity,es
dc.subjectIn vivoes
dc.titleNanotechnology-based formulations for resveratrol delivery: Effects on resveratrol in vivo bioavailability and bioactivityes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationba32f760-d55c-40a7-9452-62dfd47cbeaf
relation.isAuthorOfPublication.latestForDiscoveryba32f760-d55c-40a7-9452-62dfd47cbeaf
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