Stress and verbal memory in patients with Alzheimer’s disease: different role
of cortisol and anxiety

Gómez García, Juan; Gómez Gallego, María

Publication:
Stress and verbal memory in patients with Alzheimer’s disease: different role of cortisol and anxiety

dc.contributor.author	Gómez García, Juan
dc.contributor.author	Gómez Gallego, María
dc.contributor.department	Métodos Cuantitativos para la Economía y la Empresa
dc.date.accessioned	2024-07-10T10:59:07Z
dc.date.available	2024-07-10T10:59:07Z
dc.date.issued	2019
dc.description.abstract	ABSTRACT Objectives: Chronic stress has shown to have marked effects on learning and memory. A broader understanding of these effects has special interest in the context of Alzheimer’s disease (AD). This study aims to analyze the moderating effect of cognitive impairment in the relationships between stress and verbal memory performance by considering biological and psychological measures of stress. Method: The sample consisted of 80 AD patients and 104 healthy controls. Salivary cortisol and state anxiety was measured as stress markers. Memory Alteration test (M@T) and Hopkins verbal learning test (HVLT-R) were used to measure verbal memory. Results: In controls, cortisol level was negatively associated with HVLT-R total, learning and delayed recall scores as well as M@T free recall scores, while in patients, such associations were not significant. In this group, cortisol negative effects were limited to HVLT-R learning and M@T semantic memory scores. In both groups, anxiety was associated with better M@T encoding and free recall scores. Besides, inverted U-shaped relationships were observed between anxiety and HVLT-R total recall and learning scores as well as M@T orientation scores. Conclusion: Cortisol levels and anxiety are differentially associated with memory performance in older adults. In general, the negative relationship between cortisol levels and memory observed in healthy elderly weakens in AD. However, moderate state anxiety levels seem to be associated with a better memory performance in AD patients and in healthy elderly.	es
dc.format	application/pdf	es
dc.format.extent	8	es
dc.identifier.citation	AGING & MENTAL HEALTH 2019, VOL. 23, NO. 11, 1496–1502
dc.identifier.doi	https://doi.org/10.1080/13607863.2018.1506741
dc.identifier.uri	http://hdl.handle.net/10201/142957
dc.language	eng	es
dc.relation	Sin financiación externa a la Universidad	es
dc.rights.accessRights	info:eu-repo/semantics/restrictedAccess
dc.subject	Alzheimer’s disease	es
dc.subject	anxiety	es
dc.subject	cortisol	es
dc.subject	stress	es
dc.subject	verbal memory	es
dc.title	Stress and verbal memory in patients with Alzheimer’s disease: different role of cortisol and anxiety	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
relation.isAuthorOfPublication	44278cfb-f559-47b0-950d-fdecaf73adf3
relation.isAuthorOfPublication.latestForDiscovery	44278cfb-f559-47b0-950d-fdecaf73adf3