Publication: Melatonin modulates microfilament phenotypes in epithelial cells, implications for adhesion and inhibition of cancer cell migration
Loading...
Date
2009
Authors
Benítez-King, Gloria ; Soto-Vega, Elena ; Ramírez-Rodriguez, Gerardo
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Cell migration and adhesion are
cytoskeleton- dependent functions that play a key role in
epithelial physiology. Specialized epithelial cells in
water transport have specific microfilament
rearrangements that make these cells adopt a polyhedral
shape, forming a sealed monolayer which functions as
permeability barrier. Also, specific polarized
microfilament phenotypes are formed at the front and the
rear of migratory epithelial cells. In pathological
processes such as cancer, increased migration occurs in
invasive cells driven by the formation of polarized and
differential microfilament phenotypes. Melatonin, the
main product secreted by the pineal gland during dark
phase of the photoperiod, acts as a cytoskeletal
modulator in normal and cancer cells. In this paper we
will summarize evidence supporting that melatonin acts
as a microfilament modulator in epithelial MDCK cells,
and we will describe its effects on cytoskeleton
organization involved in the mechanism by which
melatonin synchronizes water transport. In addition, we
will review recent data that indicate that melatonin is
able to switch microfilament phenotypes in MCF-7
human mammary cancer cells, from invasive migratory
cells to dormant microfilament phenotypes that occur in
non- migratory cells. Moreover, we will discuss the
implications of the cytoskeleton as therapeutic target for
cancer cells.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.