Targeting the epigenetic machinery of cancer cells

Fernández Pérez, María Piedad; Sáez Ayala, Magalí; Cabezas Herrera, Juan; Montenegro Arce, María Fernanda; Rodríguez López, José Neptuno; Sánchez del Campo Ferrer, Luis

Publication:
Targeting the epigenetic machinery of cancer cells

dc.contributor.author	Fernández Pérez, María Piedad
dc.contributor.author	Sáez Ayala, Magalí
dc.contributor.author	Cabezas Herrera, Juan
dc.contributor.author	Montenegro Arce, María Fernanda
dc.contributor.author	Rodríguez López, José Neptuno
dc.contributor.author	Sánchez del Campo Ferrer, Luis
dc.contributor.department	Bioquímica y Biología Molecular A	es
dc.date.accessioned	2024-12-10T09:12:03Z
dc.date.available	2024-12-10T09:12:03Z
dc.date.issued	2014-01-27
dc.description	© 2014, The authors. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted version of a Published Work that appeared in final form in Oncogene. To access the final edited and published work see https://doi.org/10.1038/onc.2013.605	es
dc.description.abstract	Cancer is characterised by uncontrolled cell growth and the acquisition of metastatic properties. In most cases, the activation of oncogenes and/or deactivation of tumour suppressor genes lead to uncontrolled cell cycle progression and inactivation of apoptotic mechanisms. Although the underlying mechanisms of carcinogenesis remain unknown, increasing evidence links aberrant regulation of methylation to tumourigenesis. In addition to the methylation of DNA and histones, methylation of non-histone proteins, such as transcription factors, is also implicated in the biology and development of cancer. Because the metabolic cycling of methionine is a key pathway for many of these methylating reactions, strategies to target the epigenetic machinery of cancer cells could result in novel and efficient anti-cancer therapies. The application of these new epigenetic therapies could be of utility to promote E2F1-dependent apoptosis in cancer cells, avoid metastatic pathways and/or sensitise tumour cells to radiotherapy.	es
dc.format	application/pdf	es
dc.format.extent	29	es
dc.identifier.citation	Oncogene, 2015, Vol. 34, pp. 135–143
dc.identifier.doi	https://doi.org/10.1038/onc.2013.605
dc.identifier.issn	Print: 0950-9232
dc.identifier.issn	Electronic: 1476-5594
dc.identifier.uri	http://hdl.handle.net/10201/147266
dc.language	eng	es
dc.publisher	Springer Nature	es
dc.relation	This work was supported by grants from the Ministerio de Ciencia e Innovación (MICINN) (SAF2009-12043-C02-01) and Fundación Séneca (FS) (15230/PI/10). MFM is contracted by the Fundación de la Asociación Española contra el Cáncer (FAECC).	es
dc.relation.isreplacedby	https://doi.org/10.1038/onc.2013.605	es
dc.relation.publisherversion	https://www.nature.com/articles/onc2013605#article-info	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/4.0/	*
dc.subject	Epigenetic	es
dc.subject	Cancer	es
dc.subject	Methylation	es
dc.subject	Antifolates	es
dc.subject	Non histone proteins	es
dc.title	Targeting the epigenetic machinery of cancer cells	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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