Publication: Ultrastructural aspects of human nonunion
Authors
Quacci, Daniela ; Dell`Orbo, Carlo ; Salvi, Massimiliano ; Bartolozzi, Pietro ; Misasi, Mario
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
A histological study on the tissue of
nonunion of tibias of two young patients was performed
to evaluate the ability of cells to start the mineralization
of the matrix. The observations can be summarized as
follows: 1) Tissue vessels often appear occluded by
thrombotic material; 2) Fibroblasts and chondrocytes
found in the nonunion tissue seemed normal, with a
good secretion apparatus; 3) The cell membranes were
able to produce matrix vesicles; 4) Matrix vesicles and
cell membrane looked positive to ALPase reaction, 5)
Hydroxyapatite crystals could be observed in the cell
matrix or inside matrix vesicles.
It may be concluded that cells populating nonunion
tissue are well equipped to induct the mineralization of
the matrix, but the absence of a blood supply, enough to
bring them a normal calcium amount, is the real reason for the nonunion.
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