Publication: Hepatocyte growth factorlscatter factor, a cytokine playing multiple and converse roles
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Date
1997
Authors
Jiang, W.G. ; Hiscox, S.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Hepatocyte growth factor (HGF), otherwise
known as scatter factor (SF), is a recently identified
cytokine which exerts a wide spectrum of biological
functions on a variety of cell types. Its receptor is
encoded by the c-met proto-oncogene. HGFISF has been
implicated in the regulation of mitogenesis,
motogenesis, and morphogenesis. Over the past few
years, the structure, function and signal transduction
pathways of HGFISF and its receptor have become
clearer. The cytokine is now know to play important
roles in the regulation of both normal physiological
processes as well as pathological ones. This review
summarises recent progress involving HGFISF and its
receptor and discusses their role in cell biology, organ
regeneration, cancer and other processes.
Hepatocyte growth factor (HGF) is a pleiotropic
growth factor originally identified as a potent mitogen
agent for rat hepatocytes. Subsequent studies have
shown that it is mitogenic for a wide range of epithelial
cells and not limited to hepatocytes. Its behaviour as a
motogenic stimulator promoted its independent
discovery and naming of scatter factor (SF). Analysis of
cDNA and amino acid sequences have revealed that the
two molecules are the same. A number of cytokine
agents are known to stimulate cellular motility, however,
it is the function of HGFISF as a potent motogenic,
mitogenic and morpho-regulatory agent on the diverse
variety of cell types that makes the discovery of
HGFISF factor one of the most interesting stories in
terms of identification of novel cytokines.
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