Publication: Interocular effect of intravitreal injection of 6-hydroxydopamine and dopamine on spinule formation in teleost retina
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Date
2002
Authors
García, M. ; Grzywacz, N.M. ; De Juan, J.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Terminal dendrites of cone horizontal cells
(HCs) in teleost retinas show numerous spine-like
protrusions named spinules, which are invaginated into
the cone pedicles during light-adaptation, but retracted
during dark-adaptation. Somata of HC show
nematosomes whose size decreases as the number of
spinules increases. Mechanisms regulating these changes
in nematosomes and spinules are only partially
understood, being an area of controversy in retinal cell
biology. It has been suggested that efferent fibres from
the brain to the retina might be involved in the control of
spinule formation. Moreover, we have reported that actin
depolymerization has an interocular effect on spinule
formation, which could be mediated by these fibres. In
the present report, we show an interocular effect on
spinule dynamics: the monocular intravitreal injection of
dopamine (DA) and 6-hydroxydopamine (6-OHDA),
two drugs that affect the spinule formation, produces the
same effects in the contralateral, untreated eye as in the
injected eye. Our results reinforce the idea of an
interocular central control of this phenomenon of
synaptic plasticity. Dopamine-dependent events in the
retina appear to be necessary to forge the afferent signals
eliciting this interocular effect.
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