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Is low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?

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dc.contributor.authorZorzona Moreno, M.
dc.contributor.authorFuentes Hernández, S.
dc.contributor.authorCarrión, V.
dc.contributor.authorAlcántara López, María Vicenta
dc.contributor.authorLópez Soler, Concepción
dc.contributor.authorLarqué Daza, Elvira
dc.contributor.authorMadrid Pérez, Juan Antonio
dc.contributor.authorSánchez-Solís de Querol, Manuel
dc.contributor.departmentPersonalidad, Evaluación y Tratamiento Psicológicos
dc.contributor.otherFacultades de la UMU::Facultad de Psicología y Logopedia
dc.date.accessioned2026-02-04T12:59:00Z
dc.date.available2026-02-04T12:59:00Z
dc.date.copyright0954-3007/14
dc.date.copyright© 2014, Macmillan Publishers Limited
dc.date.issued2014-06-11
dc.description.abstractBACKGROUND/OBJECTIVE: To evaluate the relation between docosahexaenoic acid (DHA) status and neurodevelopment in the offsprings of gestational diabetic mothers (ODMs). SUBJECTS/METHODS: A prospective cohort study was performed. The offspring of 63 pregnant women (23 controls, 21 diet-controlled gestational diabetes mellitus (GDM) and 19 insulin-treated GDM) were recruited. Maternal and venous cord plasma DHA percentages were analyzed. Skin temperature and activity in children were recorded for 72 h at 3 and 6 months of life. Neurodevelopment was assessed using the Bayley Scale of Infant Development II (BSID II) at 6 and 12 months of age. RESULTS: Cord plasma DHA percentage was significantly lower in the ODMs compared with that in the controls (Control 6.43 [5.04–7.82]a; GDM+diet 5.65 [4.44–6.86]ab; GDM+insulin 5.53 [4.45–6.61]b). Both mental (Control 102.71 [97.61–107.81]a; GDM+diet100.39 [91.43–109.35]a; GDM+insulin 93.94 [88.31–99.57]b) and psychomotor (Control 91.52 [81.82–101.22]a; GDM+diet 81.67[73.95–89.39]b; GDM+insulin 81.89 [71.96–91.85]b) scores evaluated by the BSID II were significantly lower at 6 months in ODMs, even after adjusting for confounding factors such as breastfeeding, maternal educational level and gender. Cord plasma DHA percentage correlated with the psychomotor score from BSID II (r = 0.27; P = 0.049) and with the intra-daily variability in activity (r = − 0.24; P = 0.043) at 6 months. Maternal DHA was correlated with several sleep rhythm maturation parameters at 6 months. CONCLUSIONS: Lower DHA levels in cord plasma of ODMs could affect their neurodevelopment. Maternal DHA status was also associated with higher values in the sleep rhythm maturation parameters of children.
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dc.identifier.citationEuropean Journal of Clinical Nutrition (2014) 68, 931–937
dc.identifier.doihttps://doi.org/10.1038/ejcn.2014.104
dc.identifier.eissn1476-5640
dc.identifier.issn0954-3007
dc.identifier.urihttp://hdl.handle.net/10201/199149
dc.languageeng
dc.publisher Springer Nature
dc.relationThis study was supported by the Hero Institute for Infant Nutrition, Hero Spain S.A, Murcia, Spain, the Instituto de Salud Carlos II–RETICEF (RD06/0013/0019) and the Ministry of Education and Science (BFU2010-21945-C02-01). Elvira Larqué is a recipient of the ESPGHAN Award for Young Investigators 2009.
dc.relation.publisherversionhttps://www.nature.com/articles/ejcn2014104
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectDocosahexaenoic acid
dc.subjectDisturbed rhythms
dc.subjectNeurodevelopment
dc.subjectDiabetic mothers
dc.subject.odsObjetivo 3: Salud
dc.titleIs low docosahexaenoic acid associated with disturbed rhythms and neurodevelopment in offsprings of diabetic mothers?
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
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