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A contemporary picture of enterococcal endocarditis

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dc.contributor.authorPericàs, Juan M.
dc.contributor.authorLlopis, Jaume
dc.contributor.authorMuñoz, Patricia
dc.contributor.authorGálvez-Acebal, Juan
dc.contributor.authorKestler, Martha
dc.contributor.authorValerio, Maricela
dc.contributor.authorHernández-Meneses, Marta
dc.contributor.authorGoenaga, Miguel Á.
dc.contributor.authorCobo-Belaustegui, Manuel
dc.contributor.authorMontejo, Miguel
dc.contributor.authorOjeda-Burgos, Guillermo
dc.contributor.authorSousa-Regueiro, M. Dolores
dc.contributor.authorAlarcón, Arístides de
dc.contributor.authorRamos-Martínez, Antonio
dc.contributor.authorMiró, José M.
dc.contributor.authorGarcía-Vázquez, Elisa
dc.contributor.authorGAMES Investigators
dc.contributor.departmentMedicina
dc.date.accessioned2024-06-26T08:30:52Z
dc.date.available2024-06-26T08:30:52Z
dc.date.issued2020-02-03
dc.description©2020. Elsevier Inc. Todos los derechos reservados. This document is the , Published, version of a Published Work that appeared in final form in Journal of the American College Cardiology. To access the final edited and published work see https://doi.org/10.1016/j.jacc.2019.11.047es
dc.description.abstractBACKGROUND: Enterococcal endocarditis (EE) is a growing entity in Western countries. However, quality data from large studies is lacking. OBJECTIVES: The purpose of this study was to describe the characteristics and analyze the prognostic factors of EE in the GAMES cohort. METHODS: This was a post hoc analysis of a prospectively collected cohort of patients from 35 Spanish centers from 2008 to 2016. Characteristics and outcomes of 516 cases of EE were compared with those of 3,308 cases of nonenterococcal endocarditis (NEE). Logistic regression and Cox proportional hazards regression analysis were performed to investigate risk factors for in-hospital and 1-year mortality, as well as relapses. RESULTS: Patients with EE were significantly older; more frequently presented chronic lung disease, chronic heart failure, prior endocarditis, and degenerative valve disease; and had higher median age-adjusted Charlson score. EE more frequently involved the aortic valve and prosthesis (64.3% vs. 46.7%; p < 0.001; and 35.9% vs. 28.9%; p ¼ 0.002, respectively) but less frequently pacemakers/defibrillators (1.5% vs. 10.5%; p < 0.001), and showed higher rates of acute heart failure (45% vs. 38.3%; p ¼ 0.005). Cardiac surgery was less frequently performed in EE (40.7% vs.45.9%; p ¼ 0.024). No differences in in-hospital and 1-year mortality were found, whereas relapses were significantly higher in EE (3.5% vs. 1.7%; p ¼ 0.035). Increasing Charlson score, LogEuroSCORE, acute heart failure, septic shock, and paravalvular complications were risk factors for mortality, whereas prior endocarditis was protective and persistent bacteremia constituted the sole risk factor for relapse. CONCLUSIONS: Besides other baseline and clinical differences, EE more frequently affects prosthetic valves and less frequently pacemakers/defibrillators. EE presents higher rates of relapse than NEE.es
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dc.identifier.citationJ Am Coll Cardiol 2020 75(5):482–94
dc.identifier.doihttps://doi.org/10.1016/j.jacc.2019.11.047
dc.identifier.issnPrint: 0735-1097
dc.identifier.issnElectronic: 1558-3597
dc.identifier.urihttp://hdl.handle.net/10201/142700
dc.languageenges
dc.publisherElsevieres
dc.relationSin financiación externa a la Universidades
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0735109719386279es
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectEnterococcies
dc.subjectEpidemiologyes
dc.subjectHeart failurees
dc.subjectInfective endocarditises
dc.subjectProsthetic valveses
dc.subjectRelapseses
dc.titleA contemporary picture of enterococcal endocarditises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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