Publication: Thymidine phoshorylase expression in breast cancer, the prognostic significance and its association with other angiogenesis
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Date
2008
Authors
Loachim, E.
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Thymidine phosphorylase (TP)/plateletderived
endothelial cell growth factor, stimulates
chemataxis of endothelial cells and is involved in the
angiogenesis of human solid tumours. In this study we
investigated tissue sections from 93 breast carcinomas
for the immunohistochemical expression of thymidine
phosphorylase protein and in relationship to several
clinicopathological parameters. The possible relationship
to tumour neovascularization, VEGF expression,
extracellular matrix components (tenascin, fibronectin,
collagen type IV and laminin) and cathepsin D was also
estimated. Nuclear and/or cytoplasmic TP expression
was observed in tumour cells. Immunoreactivity was
also often present in the stroma, endothelium and
tumour-associated macrophages. High cytoplasmic TP
expression, was observed in 35.5%, moderate in 30.1%,
mild in 18.3%, while 16.1% of the cases were negative
for TP expression. Moderate and high nuclear TP
expression was observed in 30.1% of the tumours, low
in 43%, while 26.9% did not show nuclear TP
expression. High tumour stroma TP expression was
expressed in 23.7% of the cases, moderate in 21.5%,
mild in 45.2%, while 9.7% did not show stromal TP
expression.
TP expression did not correlate with the
conventional clinicopathological features as well as with
the microvessel density and the VEGF expression.
Patients with high levels of tumour cell TP expression
were significantly associated with a favorable outcome
in univariate method of analysis. A positive correlation
of TP expression with Cathepsin D expression was
noticed. In addition, tumour cell TP expression was
correlated with the extracellular matrix component
tenascin, while stromal cell TP expression was correlated with the growth fraction of the tumour.
Our data suggests that TP expression does not seem
to affect directly the neovasculatur of breast carcinoma,
although it seems to be implicated in the remodeling of
breast cancer tissue, through the interaction with other
extracellular matrix components or proteolytic enzymes.
In addition, tumour cell TP expression could be
considered as a prognostic indicator of breast cancer
patients.
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