Publication: Computer-aided morphometric analysis of the developing concentric structure of the human fetal intestinal tube
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Date
2002
Authors
Bagyánszki, M. ; Kovács, É.G. ; Resch, B.A. ; Román, V. ; Resch, B.E. ; Fekete, Eva
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Publisher
Murcia : F. Hernández
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DOI
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info:eu-repo/semantics/article
Description
Abstract
The Image-Pro Plus 3.0 morphometric
program was used to study the region-specific
organization of the human fetal intestine across the
radial axis of the gut at weeks 12 and 18 of gestation.
The thicknesses of the epithelium, the submucosa, the
muscular layers and the myenteric ganglia were
measured in resin-embedded semithin sections.
Statistical analysis of the collected data was performed
by using the two-way ANOVA, the SNK test and the
Pearson correlation. The structural changes relating to
the gut morphogenesis within this developmental period
were followed both light and electron microscopically.
The various tissues forming the radial axis of the
intestinal tube exhibited different trends concerning their
individual development. The thickness of the epithelium
did not change in the fetal period investigated, although
the epithelial surface displayed characteristic
ultrastructural changes. The thickness of the submucosal
layer increased significantly, but with different dynamics
along the longitudinal axis, whereas the increases in size
of the muscular layers and the myenteric ganglia did not
differ significantly along the longitudinal axis of the
embryonic intestine. The Pearson correlation revealed a
significant correlation between the development of the
circular muscle layer and that of the myenteric plexus
along the whole length of the intestinal tube. The
epithelium, the submucosa and the longitudinal muscle
layers developed independently between weeks 12 and
18 of gestation.
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