Publication: Localization of human placental glucose transporter 1 during pregnancy. An immunohistochemical study
Loading...
Date
1996
Authors
Tadokoro, C. ; Yoshimoto, Y. ; Sakata, M. ; Fujimiya, M. ; Kurachi, H. ; Adachi, E. ; Maeda, T. ; Miyake, A.
item.page.secondaryauthor
item.page.director
Publisher
Murcia : F. Hernández
publication.page.editor
publication.page.department
DOI
item.page.type
info:eu-repo/semantics/article
Description
Abstract
To elucidate the potential roles of glucose
transporter 1 (GLUTl) in human placenta during
pregnancy, we examined the localization of GLUTl in
human placenta at various stages by immunohistochemistry
with an anti-GLUT1 antibody by use of both
light and electron microscopy. Specific staining for
GLUTl was localized on the apical brush border and
along the basal plasma membrane of the syncytiotrophoblasts.
The staining at the apical side was more
intense than that at the basal side during the early stages
of gestation. In later gestational stages, however, the
staining pattern at the apical side became blurred and the
staining intensity at the basal side increased. The
cytotrophoblasts, seen embedded in the basal part of the
syncytiotrophoblasts, seemed to show immunoreactivity
for GLUTl along the plasma membranes at the lightmicroscopic
level. However, immuno-electron
microscopic analysis with either pre- or post-embedding
methods revealed that specific staining for GLUTl was
hardly observed on the cytotrophoblasts, but the
cytotrophoblasts were often surrounded by immunoreactive
processes of syncytiotrophoblasts. The blood
capillaries and erythrocytes in the stroma of placental
villi were always immunoreactive for GLUTl
throughout pregnancy. These findings suggest that
GLUTl may play a vital role in human pregnancy.
Citation
item.page.embargo
Ir a Estadísticas
Sin licencia Creative Commons.