Publication: Immunohistochemical evaluation of EGFR expression in lip squamous cell carcinoma. Correlation with clinicopathological characteristics
Authors
Carballeira, Alexo ; Ginarte, Manuel ; Diniz-Freitas, Marcio ; Fernández-Campos, Inés ; Gude, Francisco ; Fraga, Maximo ; Antúnez, José Ramón ; García-Caballero, Tomás
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
Background: The majority of lip cancer is the
squamous cell carcinoma (SCC) type that exhibits
clinical and biological characteristics intermediate
between skin and oral SCC. The aim of this study was to
assess the impact of epidermal growth factor receptor
(EGFR) expression on prognosis of lip squamous cell
carcinoma (LSCC) and to relate it with clinicopathological
features. The role of EGFR expression as a
possible therapeutic target was also discussed.
Methods: A series of 55 patients with LSCC was
analyzed. EGFR expression was determined by
standardized immunohistochemistry (pharmDx assay)
and evaluated by both manual and automated image
analysis (ACIS III). The Kappa statistic test was used to
evaluate the concordance of manual and automated
scores. EGFR results were correlated with clinicopathologic
characteristics. Statistical differences between
proportions were determined by the chi-squared test
(with linear-by-linear correction where appropriate). The
Mann-Whitney and the Kruskal-Wallis test were
employed for comparison of continuous variables.
Results: Correlation between manual and automated
score was obtained in 50/55 cases (90.9%). EGFR
expression was absent or weak in 14 cases (25.5%);
borderline (2+) in 20 cases (36.4%) and positive (3+) in
21 cases (38.2%). Significant relationships were found
between EGFR expression and tumour ulceration
(p=0.022) and tumour thickness (p=0,002) and width
(p=0.021).
Conclusions: Our results revealed EGFR high
expression in LSCC and its relationship with bad
prognosis criteria (tumour size and ulceration).
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Citation
Histology and Histopathology, vol. 29, nº 5, (2014)
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