Publication:
Carbamazepine overdose after psychiatric conditions: A case study for Postmortem Analysis in Human Bone

Simple item page
dc.contributor.authorFernández López, Lucía
dc.contributor.authorMancini, Rosanna
dc.contributor.authorRottolo, Maria Concetta
dc.contributor.authorNavarro Zaragoza, Javier
dc.contributor.authorHernández del Rincón, Juan Pedro
dc.contributor.authorFalcón Romero, María
dc.contributor.departmentFarmacología
dc.date.accessioned2026-04-13T08:55:12Z
dc.date.available2026-04-13T08:55:12Z
dc.date.copyright© 2022 by the authors
dc.date.issued2022-06-13
dc.description.abstractCarbamazepine is the main option used as a preventive medication to treat bipolar disorder when there is no response to lithium. Carbamazepine toxicity is defined as serum levels greater than 12 μg/mL, with severe toxicity occurring over 40 μg/mL, reduced to 30 μg/mL when combined with pharmacological treatment, i.e., benzodiazepines or antidepressants. For these reasons, it is necessary to find a validated tool to determine carbamazepine levels in an autopsy to rule out suicide or to know if the death was a consequence of an adverse drug reaction (ADR), especially when only bones can be accessed. We have validated a tool to detect and quantify drug concentration in bone. Our results showed a peak for carbamazepine at minute 12 and a mass fragment of 193 m/z. This case study is the first time in the literature that carbamazepine has been detected and quantified in bone. These results demonstrate that carbamazepine can be detected in bone tissue from forensic cases, but almost more importantly, that the method proposed is valid, reliable, and trustworthy.
dc.formatapplication/pdf
dc.format.extent7
dc.identifier.citationFernández-López L, Mancini R, Rotolo MC, Navarro-Zaragoza J, Hernández Del Rincón JP, Falcón M. Carbamazepine Overdose after Psychiatric Conditions: A Case Study for Postmortem Analysis in Human Bone. Toxics. 2022 Jun 13;10(6):322. doi: 10.3390/toxics10060322.
dc.identifier.doi10.3390/toxics10060322.
dc.identifier.eissn2305-6304
dc.identifier.urihttp://hdl.handle.net/10201/225282
dc.languageeng
dc.relationFUNDACIÓN SÉNECA, 20847/PI/18 and Ministerio de Ciencia e Innovación, PID2020-113081
dc.relation.publisherversionhttps://www.mdpi.com/2305-6304/10/6/322
dc.rightsAttribution 4.0 International*
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectCarbamazepine
dc.subjectBipolar
dc.subjectBone tissue
dc.subjectMatrix
dc.subjectConcentrations
dc.subjectBlood
dc.subject.odsObjetivo 3: Salud
dc.titleCarbamazepine overdose after psychiatric conditions: A case study for Postmortem Analysis in Human Bone
dc.typeinfo:eu-repo/semantics/article
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dspace.entity.typePublicationes
relation.isAuthorOfPublicationc98a9067-782e-44a8-8d14-027b35a01d90
relation.isAuthorOfPublication91a9c0cf-0115-4c34-9b53-72a417c2d883
relation.isAuthorOfPublicationb6e0add0-b2d7-4a9a-ad70-12b701f2cb29
relation.isAuthorOfPublication14cdd391-b706-46b9-8baf-04da77cd9eff
relation.isAuthorOfPublication.latestForDiscoveryc98a9067-782e-44a8-8d14-027b35a01d90
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Carbamazepine overdose after psychiatric conditions. A case study. Postmortem Analysis in Human Bone.pdf
Size:
596.94 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.37 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos