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Proteome changes induced by a short, non-cytotoxic exposure to the mycoestrogen zearalenone in the pig intestine

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dc.contributor.authorSoler, Laura
dc.contributor.authorStella, Alexandre
dc.contributor.authorPallarés, Francisco José
dc.contributor.authorLahjouji, Tarek
dc.contributor.authorBurlet Schiltz, Odile
dc.contributor.authorOswald, Isabelle P.
dc.contributor.authorSeva Alcaraz, Juan
dc.contributor.departmentAnatomía y Anatomía Patológica Comparadas
dc.date.accessioned2024-11-08T07:50:52Z
dc.date.available2024-11-08T07:50:52Z
dc.date.issued2020-07-30
dc.description© 2020 Elsevier B.V. This document is the Published version of a Published Work that appeared in final form in Journal of Proteomics. To access the final edited and published work see https://doi.org/10.1016/j.jprot.2020.103842es
dc.description.abstractIntestinal epithelial homeostasis is regulated by a complex network of signaling pathways. Among them is estrogen signaling, important for the proliferation and differentiation of epithelial cells, immune signaling and metabolism. The mycotoxin zearalenone (ZEN) is an estrogen disruptor naturally found in food and feed. The exposure of the intestine to ZEN has toxic effects including alteration of the immune status and is possibly implicated in carcinogenesis, but the molecular mechanisms linked with these effects are not clear. Our objective was to explore the proteome changes induced by a short, non-cytotoxic exposure to ZEN in the intestine using pig jejunal explants. Our results indicated that ZEN promotes little proteome changes, but significantly related with an induction of ERα signaling and a consequent disruption of highly interrelated signaling cascades, such as NF-κB, ERK1/2, CDX2 and HIF1α. The toxicity of ZEN leads also to an altered immune status characterized by the activation of the chemokine CXCR4/SDF-1 axis and an accumulation of MHC-I proteins. Our results connect the estrogen disrupting activity of ZEN with its intestinal toxic effect, associating the exposure to ZEN with cell-signaling disorders similar to those involved in the onset and progression of diseases such as cancer and chronic inflammatory disorders.es
dc.formatapplication/pdfes
dc.format.extent11es
dc.identifier.citationJournal of Proteomics, 2020, Vol. 224 : 103842
dc.identifier.doihttps://doi.org/10.1016/j.jprot.2020.103842
dc.identifier.issnPrint: 1874-3919
dc.identifier.issnElectronic: 1876-7737
dc.identifier.urihttp://hdl.handle.net/10201/146096
dc.languageenges
dc.publisherElsevieres
dc.relationThis project received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 722634 as well as by the Agence Nationale de la Recherche (ANR) grant ExpoMycoPig (ANR-17-Carn012). The work was also supported in part by the Région Occitanie, European funds (Fonds Européens de Développement Régional, FEDER), Toulouse Métropole, and the French Ministry of Research with the Investissement d'Avenir Infrastructures Nationales en Biologie et Santé program (ProFI, Proteomics French Infrastructure project, ANR-10-INBS-08).es
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1874391920302104?via%3Dihubes
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMycotoxinses
dc.subjectZearalenonees
dc.subjectIntestinees
dc.subjectPiges
dc.subjectEstrogen receptorses
dc.subjectProteomicses
dc.titleProteome changes induced by a short, non-cytotoxic exposure to the mycoestrogen zearalenone in the pig intestinees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
relation.isAuthorOfPublication.latestForDiscoveryf4f4c0d0-67f8-43f4-afa3-7bf3d0f3c03a
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