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Prospects of induced pluripotent stem cells in treating advancing Alzheimer’s disease: A review

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dc.contributor.authorPark, Juyoun Janis
dc.contributor.authorRim, Yeri Alice
dc.contributor.authorSohn, Yeowon
dc.contributor.authorNam, Yoojun
dc.contributor.authorJu, Ji Hyeon
dc.date.accessioned2025-01-15T16:33:14Z
dc.date.available2025-01-15T16:33:14Z
dc.date.issued2025
dc.description.abstractThe World Health Organization has identified Alzheimer’s disease (AD), the leading cause of dementia globally, as a public health priority. However, the complex multifactorial pathology of AD means that its etiology remains incompletely understood. Despite being recognized a century ago, incomplete knowledge has hindered the development of effective treatments for AD. Recent scientific advancements, particularly in induced pluripotent stem cell (iPSC) technology, show great promise in elucidating the fundamental mechanisms of AD. iPSCs play a dual role in regenerating damaged cells for therapeutic purposes and creating disease models to understand AD pathology and aid in drug screening. Nevertheless, as an emerging field, iPSC technology requires further technological advancement to develop effective AD treatments in the future. Thus, this review summarizes recent advances in stem cell therapies, specifically iPSCs, aimed at understanding AD pathology and developing treatmentses
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dc.format.extent14es
dc.identifier.citationHistology and Histopathology Vol. 40, nº02 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-766
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/148520
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectAlzheimer’s diseasees
dc.subjectNeurodegenerative diseasees
dc.subjectStem cellses
dc.subjectInduced pluripotent stem celles
dc.subjectDisease modelinges
dc.subjectRegenerative cell therapyes
dc.subjectDrug screeninges
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleProspects of induced pluripotent stem cells in treating advancing Alzheimer’s disease: A reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº2 (2025)