Publication:
Crosstalk between synovial macrophages and fibroblasts in rheumatoid arthritis

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dc.archivorevisado
dc.contributor.authorSaeki, Noritaka
dc.contributor.authorIma, Yuuki
dc.date.accessioned2023-11-15T10:53:20Z
dc.date.available2023-11-15T10:53:20Z
dc.date.issued2023
dc.description.abstractRheumatoid arthritis (RA) is an autoimmune disease associated with chronic inflammation of joints. Abnormally activated cells such as synovial macrophages and synovial fibroblasts induce RA pathogenesis and ultimately joint destruction. Since macrophages can change their own characteristics depending on the microenvironmental condition, it has been suggested that activation and remission of RA are regulated by crosstalk between synovial macrophages and other cells. Moreover, recent findings of heterogeneity of synovial macrophages and fibroblasts support the idea that complex interactions regulate RA from its onset to remission. Importantly, an understanding of the intercellular crosstalk in RA is far from complete. Here, we summarize the molecular mechanisms underlying the pathological development of RA with particular reference to the crosstalk between synovial macrophages and fibroblasts.es
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dc.format.extent8es
dc.identifier.citationHistology and Histopathology Vol. 38, nº11 (2023)
dc.identifier.doihttps://doi.org/10.14670/HH-18-628
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/135729
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectRheumatoid arthritises
dc.subjectCrosstalkes
dc.subjectSynovial macrophageses
dc.subjectSynovial fibroblastses
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleCrosstalk between synovial macrophages and fibroblasts in rheumatoid arthritises
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.38,nº11 (2023)