Publication:
Effects of dietary polyamines at physiologic doses in early-weaned piglets

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dc.contributor.authorSabater Molina, María
dc.contributor.authorLarqué, Elvira
dc.contributor.authorTorrella, Francisco
dc.contributor.authorPlaza, Javier
dc.contributor.authorMuñoz, Antonio
dc.contributor.authorZamora, Salvador
dc.contributor.authorLozano Parejo, Teresa
dc.contributor.departmentCiencias Sociosanitarias
dc.date.accessioned2024-02-12T11:45:26Z
dc.date.available2024-02-12T11:45:26Z
dc.date.issued2009-01-22
dc.description©2009. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Nutrition. To access the final edited and published work see https://doi.org/10.1016/j.nut.2009.01.017
dc.description.abstractObjective: Polyamines are essential for many cell functions, and they form part of the composition of maternal milk; despite this, their addition to infant formulas is currently under evaluation. The aim of the present study was to evaluate the effects of milk formulas designed to resemble sow milk supplemented with polyamines at maternal physiologic milk doses on the gut maturation of early-weaned piglets. Methods: We fed 30 newborn piglets with maternal milk (n=10), a control milk formula (n=10), or a milk formula supplemented with polyamines (5 nmol/mL of spermine and 20 nmol/mL of spermidine, n=10) for 13 d (day 2 after birth through day 15). Several growth and intestinal development parameters were measured. Results: The piglets fed the formula containing polyamine at physiologic doses showed significantly increased crypt depth in the small intestine compared with those fed with the control formula. Villus length was correlated to crypt depth. Although there were no differences in the disaccharidase activities between the animals fed the two formulas, alkaline phosphatase and gamma-glutamyl transferase activities tended to be higher in the jejunum of those fed the polyamine-supplemented diet. Dietary polyamines did not significantly modify the gut mucosal concentrations of putrescine, spermine, or spermidine. Conclusion: Milk formulas supplemented with polyamines at maternal milk physiologic doses slightly enhanced gut growth and maturation in neonatal piglets.es
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dc.format.extent7es
dc.identifier.citationNutrition 25(9) 2009: 940-946
dc.identifier.doihttps://doi.org/10.1016/j.nut.2009.01.017
dc.identifier.issnPrint: 0899-9007
dc.identifier.urihttp://hdl.handle.net/10201/139282
dc.languageenges
dc.publisherElsevier
dc.relationSin financiación externa a la Universidades
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectPolyamines
dc.subjectHuman milk
dc.subjectSmall intestine
dc.subjectGut development
dc.subjectPiglets
dc.titleEffects of dietary polyamines at physiologic doses in early-weaned pigletses
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
relation.isAuthorOfPublicationfb3c0889-f93d-4097-a67b-0ff92da16f08
relation.isAuthorOfPublication.latestForDiscoveryfb3c0889-f93d-4097-a67b-0ff92da16f08
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