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Localization of the calcium channel subunits Cav1.2 (a1C) and Cav2.3 (a1E) in the mouse organ of Corti

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dc.contributor.authorWaka, N.es
dc.contributor.authorKnipper, M.es
dc.contributor.authorEngel, J.
dc.date.accessioned2011-06-08T09:03:53Z
dc.date.available2011-06-08T09:03:53Z
dc.date.issued2003
dc.description.abstractVoltage-activated Ca2+ channels play an important role in synaptic transmission, signal processing and development. The immunohistochemical localization of Cav1.2 (a1C) and Cav2.3 (a1E) Ca2+ channels was studied in the developing and adult mouse organ of Corti using subunit-specific antibodies and fluorescent secondary antibodies with cochlear cryosections. Cav1.2 immunoreactivity has been detected from postnatal day 14 (P14) onwards at the synapses between cholinergic medial efferents and outer hair cells as revealed by co-staining with antisynaptophysin and anti-choline acetyltransferase. Most likely the Cav1.2 immunoreactivity was located presynaptically at the site of contact of the efferent bouton with the outer hair cell which suggests a role for class C L-type Ca2+ channels in synaptic transmission of the medial efferent system. The localization of the second Ca2+ channel tested, Cav2.3, showed a pronounced change during cochlear development. From P2 until P10, Cav2.3 immunoreactivity was found in the outer spiral bundle followed by the inner spiral bundle, efferent endings and by medial efferent fibers. Around P14, Cav2.3 immunoreactivity disappeared from these structures and from P19 onwards it was observed in the basal poles of the outer hair cell membranes.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21478
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectCalcium channeles
dc.subjectDevelopmentes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicinaes
dc.titleLocalization of the calcium channel subunits Cav1.2 (a1C) and Cav2.3 (a1E) in the mouse organ of Corties
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.18, nº 4 (2003)