Publication:
Seminal extracellular vesicles and their involvement in male (In)fertility: a systematic review

Simple item page
dc.contributor.authorParra, Ana
dc.contributor.authorPadilla, Lorena
dc.contributor.authorLucas, Xiomara
dc.contributor.authorRodríguez Martínez, Heriberto
dc.contributor.authorBarranco, Isabel
dc.contributor.authorRoca, Jordi
dc.contributor.departmentMedicina y Cirugía Animal
dc.date.accessioned2024-09-05T10:00:27Z
dc.date.available2024-09-05T10:00:27Z
dc.date.issued2023-03-02
dc.description© 2023 by the authors. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in International Journal of Molecular Sciences. To access the final edited and published work see https://doi.org/10.3390/ijms24054818
dc.description.abstractSeminal plasma contains numerous extracellular vesicles (sEVs). Since sEVs are apparently involved in male (in)fertility, this systematic review focused on studies specifically investigating such relationship. Embase, PubMed, and Scopus databases were searched up to 31 December 2022, primarily identifying a total of 1440 articles. After processing for screening and eligibility, 305 studies were selected as they focused on sEVs, and 42 of them were considered eligible because they included the word fertility or a related word such as infertility, subfertility, fertilization, and recurrent pregnancy loss in the title, objective(s), and/or keywords. Only nine of them met the inclusion criteria, namely (a) conducting experiments aimed at associating sEVs with fertility concerns and (b) isolating and adequately characterizing sEVs. Six studies were conducted on humans, two on laboratory animals, and one on livestock. The studies highlighted some sEV molecules, specifically proteins and small non-coding RNAs, that showed differences between fertile and subfertile or infertile males. The content of sEVs was also related to sperm fertilizing capacity, embryo development, and implantation. Bioinformatic analysis revealed that several of the highlighted sEV fertility-related proteins would be cross-linked to each other and involved in biological pathways related to (i) EV release and loading and (ii) plasma membrane organization.es
dc.formatapplication/pdfes
dc.format.extent15es
dc.identifier.citationInt. J. Mol. Sci. 2023, 24, 4818
dc.identifier.doihttps://doi.org/10.3390/ijms24054818
dc.identifier.issnPrint: 1661-6596
dc.identifier.issnElectronic: 1422-0067
dc.identifier.urihttp://hdl.handle.net/10201/143625
dc.languageenges
dc.publisherMDPI
dc.relationThis study was funded by the Spanish Ministry of Science and Innovation (Grant PID2020-113493RB-I00 founded by MCIN/AEI/10.13039/501100011033), Madrid, Spain; and the Research Council FORMAS (Project 2019-00288), Stockholm, Sweden. L.P was financially supported by the Ministry of Universities (Spain) and by European Union-Next Generation EU Funds (Margarita Salas Scheme) and I.B. by the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement no. 891382.es
dc.relation.publisherversionhttps://www.mdpi.com/1422-0067/24/5/4818es
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAtribución 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/*
dc.subjectSeminal plasmaes
dc.subjectExtracellular vesicles
dc.subjectFertility
dc.subjectInfertility
dc.subjectProteins
dc.subjectSncRNAs
dc.titleSeminal extracellular vesicles and their involvement in male (In)fertility: a systematic reviewes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
ijms-24-04818.pdf
Size:
5.94 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
2.26 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos