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Morphological and molecular aspects of lung development

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dc.contributor.authorSchmiedl, Andreas
dc.contributor.authorMühlfeld, Christian
dc.date.accessioned2025-03-18T08:19:08Z
dc.date.available2025-03-18T08:19:08Z
dc.date.issued2025
dc.description.abstractHealthy breathing relies on normal morphological and functional development of the lung. This includes different prenatal and postnatal developmental stages. Depending on species and postnatal behavior as nest escapers or nest squatters, the duration of individual developmental phases and the state of differentiation of the lungs at birth differ. However, the sequence and morphology of the lung developmental stages are similar in all mammals, so knowledge gained from animal models about development-specific genetic control and regulatory mechanisms can be translated in principle to the human lung. Functional lung development comprises the maturation of the surfactant system, which is closely linked to the morphological development of the pulmonary acini. Although a number of reviews are found in the literature, a presentation that integrates the morphological and molecular regulatory mechanisms is missing. Therefore, the aim of this article was to provide an up-to-date comprehensive review of the main morphological steps and regulatory mechanisms of lung development, including clinical aspects related to developmental disorders.es
dc.formatapplication/pdfes
dc.format.extent20es
dc.identifier.citationHistology and Histopathology Vol. 40, nº04 (2025)
dc.identifier.doihttps://doi.org/10.14670/HH-18-807
dc.identifier.issn0213-3911
dc.identifier.issn1699-5848
dc.identifier.urihttp://hdl.handle.net/10201/151820
dc.languageenges
dc.publisherUniversidad de Murcia, Departamento de Biologia Celular e Histiologiaes
dc.relationSin financiación externa a la Universidades
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 Internacional*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectLung developmentes
dc.subjectMolecular factorses
dc.subjectLung morphogenesises
dc.subjectBranchinges
dc.subjectAlveolarizationes
dc.subjectMicro vascular maturationes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleMorphological and molecular aspects of lung developmentes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.40, nº4 (2025)