Verapamil blocks scopolamine enhancement effect on memory consolidation in passive avoidance task in rats

Giménez de Béjar, Verónica; Caballero Bleda, María; Popovic, Natalija; Popovic Popovic, Miroljub

Publication:
Verapamil blocks scopolamine enhancement effect on memory consolidation in passive avoidance task in rats

dc.contributor.author	Giménez de Béjar, Verónica
dc.contributor.author	Caballero Bleda, María
dc.contributor.author	Popovic, Natalija
dc.contributor.author	Popovic Popovic, Miroljub
dc.contributor.department	Anatomía Humana y Psicobiología
dc.date.accessioned	2024-06-18T10:36:32Z
dc.date.available	2024-06-18T10:36:32Z
dc.date.issued	2017-08-23
dc.description	© 2017 Giménez De Béjar, Caballero Bleda, Popovic and Popovic. This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Frontiers in Pharmacology. To access the final edited and published work see https://doi.org/10.3389/fphar.2017.00566
dc.description.abstract	Our recent data have indicated that scopolamine, a non-selective muscarinic receptor antagonist, improves memory consolidation, in a passive avoidance task, tested in rats. It has been found that verapamil, a phenylalkylamine class of the L-type voltage-dependent calcium channel antagonist, inhibits [3H] N-methyl scopolamine binding to M1 muscarinic receptors. However, there are no data about the effect of verapamil on memory consolidation in the passive avoidance task, in rats. The purpose of the present study was to examine the effects of verapamil (0.5, 1.0, 2.5, 5.0, 10, or 20 mg/kg i.p.) as well as the interaction between scopolamine and verapamil on memory consolidation in the step-through passive avoidance task, in Wistar rats. Our results showed that verapamil (1.0 and 2.5 mg/kg) administered immediately after the acquisition task significantly increased the latency of the passive avoidance response, on the 48 h retested trial, improving memory consolidation. On the other hand, verapamil in a dose of 5 mg/kg, that per se does not affect memory consolidation, significantly reversed the memory consolidation improvement induced by scopolamine (1 mg/kg, i.p., administered immediately after verapamil treatment) but did not change the passive avoidance response in rats treated by an ineffective dose of scopolamine (30 mg/kg). In conclusion, the present data suggest that (1) the post-training administration of verapamil, dose-dependently, improves the passive avoidance response; (2) verapamil, in ineffective dose, abolished the improvement of memory consolidation effect of scopolamine; and (3) exists interaction between cholinergic muscarinic receptors and calcium homeostasis-related mechanisms in the consolidation of emotional memory.	es
dc.format	application/pdf	es
dc.format.extent	9	es
dc.identifier.citation	Front Pharmacol. 2017 8:566.
dc.identifier.doi	https://doi.org/10.3389/fphar.2017.00566
dc.identifier.issn	Electronic: 1663-9812
dc.identifier.uri	http://hdl.handle.net/10201/142386
dc.language	eng	es
dc.publisher	Frontiers Media	es
dc.relation	Funding for this study was provided by the Health Council of Murcia Region, Spain (MC), the Spanish Ministry of Economy and Competitiveness (BFU2014-57516-P; LPL, JLF), and the European Regional Development Fund (EFDR; LPL). The funding source had no further role in the study design; in the collection, analysis, and interpretation of the data; in the writing of the report; or in the decision to submit the paper for publication.	es
dc.relation.publisherversion	https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2017.00566/full	es
dc.rights	info:eu-repo/semantics/openAccess	es
dc.rights	Atribución 4.0 Internacional	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	*
dc.subject	Memory consolidation	es
dc.subject	Passive avoidance	es
dc.subject	Verapamil	es
dc.subject	Scopolamine	es
dc.subject	Rat	es
dc.subject.other	CDU::6 - Ciencias aplicadas	es
dc.title	Verapamil blocks scopolamine enhancement effect on memory consolidation in passive avoidance task in rats	es
dc.type	info:eu-repo/semantics/article	es
dspace.entity.type	Publication	es
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relation.isAuthorOfPublication.latestForDiscovery	dc3015b4-805d-4b6e-a49f-f2d73bb3c2b2