Publication: Expression of integrins αvß3 and αvß5
and their ligands in primary and secondary
central nervous system neoplasms
Authors
Mittelbronn, Michel ; Warth, Arne ; Meyermann, Richard ; Goodman, Simon ; Weller, Michael
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Publisher
F. Hernández y Juan F. Madrid. Universidad de Murcia: Departamento de Biología Celular e Histología
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DOI
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info:eu-repo/semantics/article
Description
Abstract
. Aims: To study the expression of integrins
αvß3 and αvß5 and their ligands in tumour, stroma and
endothelial cells from human glioblastoma and CNS
metastases from breast, lung and skin tumours. Methods
and results: Integrin and integrin ligand expression was
quantified in frozen tumour surgical specimens (15
glioblastomas and breast carcinoma metastases as well
as 16 lung carcinoma and melanoma metastases) using
immunohistochemistry. Gene expression profiles were
evaluated in glioblastomas (n=424) and in normal brain
(n=11). Overall, αvß3 expression was more common
than αvß5, except in tumours derived from lung. αvß3
expression was most frequent in glioblastomas and
melanoma metastases. Most lung-derived tumours
expressed αvß5, but expression was less frequent in
other tumours; about 20% of breast-derived tumours
strongly expressed αvß5. Melanoma-derived tumours
did not express αvß5. Expression of integrin ligands
vitronectin, fibrinogen, fibronectin and osteopontin was
variable between tumours, although most tumours
expressed the ligands to some extent. Marked αvß3, but
not αvß5, expression was common in stroma of CNS
metastases. In blood vessels, αvß3 expression was more
frequent than αvß5 and more pronounced in CNS
metastases than in glioblastomas. Integrin ligand
expression occurred in blood vessels in most tumours. In
glioblastomas, mRNA expression of αvß3, αvß5,
osteopontin and fibronectin were significantly
upregulated over normal brain. Conclusions: Overall, we
report distinct and heterogeneous patterns of integrin
expression in primary and secondary brain tumours that
may be relevant to the future development of integrintargeting
therapeutic approaches to brain tumours.
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Citation
Histology and Histopathology, vol. 28, nº 6, (2013)
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