Publication: Roles of long-non-coding RNAs in cancer therapy through the PI3K/Akt signalling pathway
Authors
Ting-Wei Lee, Katherine ; Gopalan, Vinod ; King-yin Lam, Alfred
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Publisher
Universidad de Murcia. Departamento de BiologĂa Celular e HistologĂa
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DOI
DOI: 10.14670/HH-18-081
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info:eu-repo/semantics/article
Description
Abstract
The vital need for Akt in maintaining basic
cellular function has highlighted its importance in
carcinogenesis. Unfortunately, Akt inhibitor
development outcome has remained poor, as most of
them have failed to show significant clinical benefit to
cancer patients during the clinical trials. Recently, a new
class of non-coding RNAs, known as long non-coding
RNAs (lncRNAs), which show high tissue specificity,
have demonstrated great influence in cancer progression
and/or cancer inhibition. As both Akt signalling
pathways and lncRNAs play such innate roles in
carcinogenesis, identifying the specific roles that these
lncRNAs play within this pathway may represent a novel
research avenue for developing Akt inhibitors with
better therapeutic properties. In addition, understanding
the diverse mechanism by which lncRNAs regulate gene
expression can assist in deciphering the fundamentals of
carcinogenesis. The focus of interest should be on the
lncRNAs, which affect Akt and finding the link between
lncRNAs and Akt pathways associated with
carcinogenesis. LncRNAs within the Akt pathways
could affect multiple pathways in a particular cancer
type, which ultimately creates an intricate web of
connections between the pathways. In summary,
lncRNAs have tremendous potential in cancer diagnosis,
assessing cancer patient prognosis and in developing
new therapeutic options for patients with resistance to
current cancer therapies. Thus, understanding how
lncRNAs influence the Akt pathway is essential for the
development of novel and effective cancer therapies.
Citation
Histology and Histopathology, Vol.34, nÂş6, (2019)
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