Publication: Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and
Aversive Memories
Authors
Gómez-Murcia, Victoria ; Gómez-Fernández, Juan Carmelo ; Almela, Pilar ; Ribeiro do Couto, Bruno ; Laorden Carrasco, María Luisa ; Milanés Maquilón, María Victoria
item.page.secondaryauthor
item.page.director
Publisher
Frontiers Media
publication.page.editor
publication.page.department
DOI
doi: 10.3389/fphar.2019.01082
item.page.type
info:eu-repo/semantics/article
Description
Abstract
Morphine is thoroughly used for pain control; however, it has a high addictive potential. Opioid liposome formulations produce controlled drug release and have been thoroughly tested for pain treatment although their role in addiction is still unknown. This study investigated the effects of free morphine and morphine encapsulated in unilamellar and multilamellar liposomes on antinociception and on the expression and extinction of the positive and negative memories associated with environmental cues. The hot plate test was used to measure central pain. The rewarding effects of morphine were analyzed by the conditioned-place preference (CPP) test, and the aversive aspects of naloxone-precipitated morphine withdrawal were evaluated by the conditioned-place aversion (CPA) paradigm. Our results show that encapsulated morphine yields prolonged antinociceptive effects compared with the free form, and that CPP and CPA expression were similar in the free- or encapsulated-morphine groups. However, we demonstrate, for the first time, that morphine encapsulation reduces the duration of reward and aversive memories, suggesting that this technological process could transform morphine into a potentially less addictive drug. Morphine encapsulation in liposomes could represent a pharmacological approach for enhancing extinction, which might lead to effective clinical treatments in drug addiction with fewer side effects
publication.page.subject
Citation
Front. Pharmacol. 10:1082. 2019
item.page.embargo
Collections
Ir a Estadísticas
Este ítem está sujeto a una licencia Creative Commons. http://creativecommons.org/licenses/by-nc-nd/4.0/