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Ischemic preconditioning: tolerance to hepatic ischemia-reperfusion injury

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dc.contributor.authorSerafín, A.es
dc.contributor.authorFernández-Zabalegui, L.es
dc.contributor.authorPrat, Narcis
dc.contributor.authorWu, Z.Y.
dc.contributor.authorRoselló-Catafau, J.
dc.contributor.authorPeralta, C.
dc.date.accessioned2011-06-08T09:04:36Z
dc.date.available2011-06-08T09:04:36Z
dc.date.issued2004
dc.description.abstractHepatic ischemia-reperfusion (I/R) injury still remains an unresolved problem in both liver resectional surgery and liver transplantation and may be responsible for liver failure, lung injury and death. The current review summarizes the findings reported to date on the effectiveness of ischemic preconditioning against liver and lung damage associated with hepatic I/R injury and the underlying protective mechanisms. The effect of ischemic preconditioning on the mechanisms potentially involved in hepatic I/R injury, including alterations in energy metabolism, neutrophil accumulation, microcirculatory disturbances, formation of proinflammatory mediators, such as endothelin and tumor necrosis factor-alpha, and reactive oxygen species generation have been evaluated. In this review, we address the role of preconditioning in the increased vulnerability of fatty livers to hepatic I/R injury. The effectiveness of ischemic preconditioning versus pharmacological strategies that could simulate the benefits of liver preconditioning has been also discussed.es
dc.formatapplication/pdfes
dc.format.extent9es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/21523
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectIschemiaes
dc.subjectReperfusiones
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.titleIschemic preconditioning: tolerance to hepatic ischemia-reperfusion injuryes
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol.19, nº 1 (2004)