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«Neuroendocrine» differentiation in hepatocellular carcinomas (HCCs): lmmunohistochemical reactivity is related to distinct tumor cell types, but not to tumor grade

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dc.contributor.authorZhao, M.es
dc.contributor.authorLaissue, J.A.es
dc.contributor.authorZimmermann, Astrid
dc.date.accessioned2011-02-01T09:17:20Z
dc.date.available2011-02-01T09:17:20Z
dc.date.issued1993
dc.description.abstractWe have analyzed neuroendocrine differentiation (ND) in hepatocellular carcinomas (HCCs) of fifty patients. It turned out that ND is frequent in HCCs, and that it is not restricted to fibrolamellar hepatocellular carcinoma (FL-HCC). Multiexpression is seen in a quarter of the cases, and marker coexpression may occur within the same tumor cell. ND predominates in trabecular and rnixed HCCs, but does not appear to be related to grade. Most positive cases showed a hepatocyte-like cell morphology, frequently associated with bile formation. It thus appears that the HCC cell type most likely to show ND is a hepatocyte-like one, i.e. differentiated cell, frequently polarized and producing bile, rather than a small and poorly-differentiated cell. Possible pathogenic mechanisms leading to ND in HCCs are briefly discussed.es
dc.formatapplication/pdfes
dc.format.extent10es
dc.identifier.issn0213-3911es
dc.identifier.urihttp://hdl.handle.net/10201/18452
dc.languageenges
dc.publisherMurcia : F. Hernándezes
dc.relation.ispartofHistology and histopathologyes
dc.rightsinfo:eu-repo/semantics/openAccesses
dc.subjectNeuroendocrine cellses
dc.subjectHepatocellular carcinomaes
dc.subject.otherCDU::6 - Ciencias aplicadas::61 - Medicina::616 - Patología. Medicina clínica. Oncologíaes
dc.title«Neuroendocrine» differentiation in hepatocellular carcinomas (HCCs): lmmunohistochemical reactivity is related to distinct tumor cell types, but not to tumor gradees
dc.typeinfo:eu-repo/semantics/articlees
dspace.entity.typePublicationes
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Histology and histopathology Vol. 8, nº 4 (1993)